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Merck
CN

MAK008

Hydroxyproline Assay Kit

sufficient for 100 colorimetric tests

Synonym(s):

Hydroxyproline Quantification Kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503
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usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

dermatological diseases

shipped in

wet ice

storage temp.

2-8°C

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General description

Hydroxyproline (4-hydroxyproline) is a non-proteinogenic amino acid formed by the post-translational hydroxylation of proline. Hydroxyproline is a major component of collagen, where it serves to stabilize the helical structure. Because hydroxyproline is largely restricted to collagen, the measurement of hydroxylproline levels can be used as an indicator of collagen content. Conditions that increase collagen turnover can elevate serum and urine hydroxyproline levels. Urine and serum hydroxyproline levels can be used as a marker for bone resorption.

Application

Hydroxyproline Assay Kit has been used to determine the concentration of hydroxyproline and collagen.
Suitable for hydroxyproline detection in cell and tissue culture supernatants, urine, plasma, serum, and other biological samples.

Biochem/physiol Actions

In the Hydroxyproline Assay Kit, hydroxyproline concentration is determined by the reaction of oxidized hydroxyproline with 4-(Dimethylamino)benzaldehyde (DMAB), which results in a colorimetric (560 nm) product, proportional to the hydroxyproline present.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Ox. Liq. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system, Thyroid

supp_hazards

Storage Class

5.1B - Oxidizing hazardous materials

flash_point_f

64.4 °F

flash_point_c

18 °C

Regulatory Information

危险化学品
易制爆化学品

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Krysta Powers et al.
The Journal of experimental biology, 220(Pt 17), 3110-3118 (2017-06-24)
In actively stretched skeletal muscle sarcomeres, titin-based force is enhanced, increasing the stiffness of active sarcomeres. Titin force enhancement in sarcomeres is vastly reduced in
Lodish H, et al.
Molecular Cell Biology. 4th edition. (2000)
Urinary biochemical markers for bone resorption during the menstrual cycle.
Gorai I, et al.
Calcified Tissue International, 57(2), 100-104 (1995)
Gianluca Moroncini et al.
PloS one, 13(6), e0196048-e0196048 (2018-06-02)
Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we
Boon Chin Heng et al.
Journal of endodontics, 43(3), 409-416 (2017-02-25)
Dental follicle stem cells (DFSCs) possess neurogenic potential because they originate from the embryonic neural crest. This study investigated whether neural differentiation of DFSCs can be enhanced by culture on decellularized matrix substrata (NSC-DECM) derived from neurogenesis of human embryonic

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Global Trade Item Number

SKUGTIN
MAK008-1KT04061835546930

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