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Merck
CN

MAK020

Fructose-6-Phosphate Assay Kit

sufficient for 100 fluorometric tests

Synonym(s):

Fructose-6-P Quantification Kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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Product Name

Fructose-6-Phosphate Assay Kit, sufficient for 100 fluorometric tests

usage

sufficient for 100 fluorometric tests

detection method

fluorometric

relevant disease(s)

cancer

storage temp.

−20°C

Application

Fructose-6-Phosphate Assay Kit has been used to measure fructose-6-phosphate (F-6-P) and glucose-6-phosphate (G6P).
Suitable for quantifying Fructose-6-Phosphate in a variety of samples

Biochem/physiol Actions

Fructose-6-phosphate concentration is determined by a coupled enzyme reaction, which results in a fluorometric (λex = 535 nm/λem = 587 nm) product, proportional to the fructose-6-phosphate present. Typical sensitivities for this kit are 0.01 to 0.5 nmoles of F6P.

General description

Fructose-6-phosphate (F6P) is a glycolytic pathway intermediate produced by the isomerization of glucose-6-phosphate by phosphoglucose isomerase. F6P is further phosphorylated to fructose 1,6-biphosphate which is subsequently cleaved to glyceraldehyde phosphate and dihydroxyacetone phosphate. F6P can also be shunted from glycolysis to the non-oxidative branch of the pentose phosphate pathway as a means of generative pentose phosphates for nucleotide synthesis. F6P levels are elevated in rapidly proliferating cells such as cancer cells. The Fructose-6-phosphate Assay Kit is a highly sensitive and simple fluorescence-based method of quantifying F6P in a variety of samples.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
8M12K06890
7E28K06890
6M28K06890
5E07K06890
5E073K0689

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Kenichi Matsumoto et al.
Cancer letters, 500, 29-40 (2020-12-12)
Glycolysis emerges as a new therapeutic target for malignancies. The inhibition of glycolytic activator, PFKFB3, repairs tumor endothelial cell function, and normalizing the tumor microenvironment. We aimed to investigate the significance of PFKFB3 in HCC, and the effects of the
Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells.
Yao B, et al.
Cellular Signalling, 28(11) (2016)
Minle Li et al.
Cell death & disease, 13(2), 99-99 (2022-02-04)
Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates in maintaining ribose 5-phosphate levels. TKT is necessary for maintaining cell growth. However, we found that in addition to this, TKT can also affect tumor
Proteomic and biochemical basis for enhanced growth yield of Enterobacter sp. LCR1 on insoluble phosphate medium.
Kumar A and Rai L C
Microbiological research, 170 (2015)
Sicheng Gao et al.
DNA and cell biology, 38(4), 286-296 (2019-02-15)
Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature of cancer and contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc and β-catenin, and explored their effects on the progression of liver cancer.
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