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Merck
CN

MAK094

Sigma-Aldrich

Protein Carbonyl Content Assay Kit

sufficient for 100 colorimetric tests

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

Key Documents

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usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

cardiovascular diseases; neurological disorders; cancer; gastrointestinal diseases

storage temp.

2-8°C

General description

Oxidative stress results when the effectiveness of antioxidant defenses is insufficient to deal with the production of reactive oxygen species (ROS). ROS can induce damage to DNA, lipids, and proteins. The oxidation of proteins results in the production of stable carbonyl groups, which can be used as a measure of oxidative injury.

Application

Protein carbonyl content assay kit has been used to determine protein carbonyl concentration.
Suitable for quantifying carbonyls in protein samples

Biochem/physiol Actions

The Protein Carbonyl Content Assay Kit provides a simple and direct procedure for measuring carbonyl content in a variety of biological samples. Carbonyl content is determined by the derivatization of protein carbonyl groups with 2,4-dinitrophenylhydrazine (DNPH) leading to the formation of stable dinitrophenyl (DNP) hydrazone adducts, which can be detected spectrophotometrically at 375 nm, proportional to the carbonyls present.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Corr. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
8M13K08300
8F16K08300
8B07K08300
7L05K08300
7E05K08300

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J O Zeitz et al.
Journal of animal physiology and animal nutrition, 102(4), 999-1011 (2018-05-01)
This study hypothesized that plasma and tissue antioxidant status of broilers is positively influenced when dietary Met concentrations exceed, and negatively when they go below NRC recommendations. In addition, different Met sources are hypothesized to affect the antioxidant defence system
Mohammad Arif et al.
Toxicology and industrial health, 34(4), 213-218 (2018-03-10)
Lead exposure can damage cells directly by effecting DNA or indirectly by modifying proteins and enzymes. In Bangladesh, many working children are exposed to a very high level of lead during their early life due to their involvement with lead-oriented
Kirk E Anderson et al.
Microbiome, 6(1), 108-108 (2018-06-20)
In social insects, identical genotypes can show extreme lifespan variation providing a unique perspective on age-associated microbial succession. In honey bees, short- and long-lived host phenotypes are polarized by a suite of age-associated factors including hormones, nutrition, immune senescence, and
UV?B radiation interacts with temperature to determine animal performance.
Ghanizadeh-Kazerouni E, et al.
Functional Ecology, 30(4), 584-595 (2016)
Benjamin W B Holman et al.
Meat science, 139, 171-178 (2018-02-11)
Different chilled (~0.1 °C for up to 5 weeks) then frozen storage (up to 12 months) combinations and two frozen storage holding temperatures (-12 °C and -18 °C) effects on beef M. longissimus lumborum (LL) protein structure degradation and a marker of protein oxidation were
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