MAK152
Colorimetric Sphingomyelinase Assay Kit
sufficient for 200 colorimetric tests
Synonym(s):
Neutral Sphingomyelinase Assay Kit
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
usage
sufficient for 200 colorimetric tests
detection method
colorimetric
relevant disease(s)
rheumatological diseases; cancer
storage temp.
−20°C
Gene Information
human ... SMPD2(6610), SMPD3(55512), SMPD4(55627)
mouse ... SMPD2(20598), SMPD3(58994), SMPD4(77626)
rat ... SMPD2(83537), SMPD3(94338), SMPD4(303790)
Related Categories
General description
Sphingomyelinase (SMase), or sphingomyelin phosphodiesterase, catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide, a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence, cellular location, and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases, along with the acidic SMases, are thought to be major contributors to the production of ceramide in response to cellular stress.
Application
This kit is suitable for the detection of sphingomyelinase activity in a variety of samples such as blood and cell extracts or for screening sphingomyelinase inhibitors and activators.
Biochem/physiol Actions
The Sphingomyelinase Assay Kit provides a simple and direct procedure for measuring neutral SMase activity in a variety of samples such as blood or cell extracts, or for screening SMase activators and inhibitors. SMase activity is determined by a coupled enzyme assay, which results in a colorimetric (655 nm) product proportional to the SMase activity present.
Features and Benefits
Compatible with high-throughput handling systems.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
10 - Combustible liquids
Regulatory Information
监管及禁止进口产品
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Javad Habibi et al.
Journal of molecular and cellular cardiology, 167, 32-39 (2022-03-26)
Sphingomyelinases ensure ceramide production and play an integral role in cell turnover, inward budding of vesicles and outward release of exosomes. Recent data indicate a unique role for neutral sphingomyelinase (nSMase) in the control of ceramide-dependent exosome release and inflammatory
Wojciech Łuczaj et al.
Antioxidants (Basel, Switzerland), 9(12) (2020-12-02)
UV radiation is a well-established environmental risk factor known to cause oxidative stress and disrupt the metabolism of keratinocyte phospholipids. Cannabidiol (CBD) is a phytocannabinoid with anti-inflammatory and antioxidant effects. In this study, we examined changes in the keratinocyte phospholipid
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