MAK184
Succinate Colorimetric Assay Kit
Sufficient for 100 Colorimetric tests
Synonym(s):
Succinic Acid Assay Kit
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About This Item
UNSPSC Code:
12161503
EC Number:
205-778-7
NACRES:
NA.84
application(s)
cosmetics
food and beverages
detection method
colorimetric
relevant disease(s)
cardiovascular diseases; immunological diseases
storage temp.
−20°C
General description
Succinate (succinic acid) is a citric acid cycle intermediate and functions in the transport of electrons to the mitochondrial electron transport chain. It also functions in innate immune signaling and induces IL-1β production during inflammation. Succinates have been often used for the treatment of hypertension. Succinate measurements can be useful for studying its metabolic, immunological, and therapeutic activities.
Application
Succinate Colorimetric Assay Kit has been used to measure the concentration of succinate.
Suitable for the detection of succinate in a variety of samples such as cell and tissue culture supernatants and in liquid samples such as wine.
Biochem/physiol Actions
The Succinate Colorimetric Assay Kit is a highly sensitive assay for determining succinate levels (ranging from 2-10 nmole/well) in a variety of samples. Succinate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product proportional to the succinate present.
Kit Components Only
Product No.
Description
- Succinate Assay Buffer
- Succinate Converter
- Succinate Enzyme Mix
- Succinate Substrate Mix
- Succinate Developer
- Succinate Standard
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
Regulatory Information
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VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Li J, et al.
Nature Communications, 8(1), 1322-1322 (2017)
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, et al.
JCI insight, 2(12) (2017)
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Hainer JW and Jennifer S
Vascular Health, 3(3), 279-279 (2007)
Kimberly L Cramer-Morales et al.
Journal of Experimental Pathology, 1(2), 60-70 (2021-02-16)
Previous studies showed that human cell line HEK293 lacking mitochondrial superoxide dismutase (MnSOD) exhibited decreased succinate dehydrogenase (SDH) activity, and mice lacking MnSOD displayed significant reductions in SDH and aconitase activities. Since MnSOD has significant effects on SDH activity, and
Yurong Zhang et al.
Redox biology, 28, 101365-101365 (2019-11-11)
Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is unclear whether succinate accumulation contributes to the onset of epilepsy or seizures. We sought to investigate changes in
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