MAK202
Cathepsin S Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
CTSS Inhibitor Assay Kit
detection method
fluorometric
relevant disease(s)
endocrinological disorders, diabetes; cardiovascular diseases; cancer
storage temp.
−20°C
Gene Information
human ... CTSS(1520)
mouse ... CTSS(13040)
rat ... CTSS(50654)
General description
Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.
Application
Suitable for the screening of inhibitors of Cathepsin S.
Biochem/physiol Actions
The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.
Kit Components Only
Product No.
Description
- CTSS Reaction Buffer
- Cathepsin S, human
- CTSS Substrate, Z-VVR-AFC, 10 mM
- CTSS Inhibitor Z-FF-FMK, 1 mM
Storage Class
10 - Combustible liquids
Regulatory Information
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