MAK213
Neutrophil Elastase Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
Neutrophil Elastase Inhibition Assay Kit
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About This Item
UNSPSC Code:
12352200
EC Number:
232-670-7
NACRES:
NA.25
detection method
fluorometric
storage temp.
−20°C
Gene Information
human ... ELANE(1991)
mouse ... ELANE(50701)
rat ... ELANE(299606)
General description
Neutrophil elastase (NE) is a serine protease that hydrolyzes proteins within the azurophilic granules of the neutrophils. Once secreted, it digests collagen-VI and elastin of the extracellular matrix. Neutrophil elastase is implicated in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, congenital neutropenia, and lung cancer.
Application
Suitable for the screening of inhibitors of Neutrophil Elastase.
Biochem/physiol Actions
The Neutrophil Elastase Inhibitor Screening Kit is a rapid, sensitive and high throughput assay to screen and characterize potential inhibitors of NE. NE activity is measured by hydrolyzing the substrate to yield a fluorescent product (λex = 400/λem = 505 nm) proportional to the enzymatic activity present.
Features and Benefits
Compatible with high-throughput handling systems.
Kit Components Only
Product No.
Description
- Assay Buffer
- Substrate
- Neutrophil Elastase
- Inhibitor Control, 3 mM SPCK
Storage Class
10 - Combustible liquids
Regulatory Information
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13th ACS Winter Fluorine Conference, paper No. 8 null
Lucas Paoli et al.
Nature, 607(7917), 111-118 (2022-06-23)
Natural microbial communities are phylogenetically and metabolically diverse. In addition to underexplored organismal groups1, this diversity encompasses a rich discovery potential for ecologically and biotechnologically relevant enzymes and biochemical compounds2,3. However, studying this diversity to identify genomic pathways for the
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
Horwitz M S, et al.
Hematology/oncology Clinics of North America, 27, 19?41-19?41 (2013)
Neutrophil elastase as a target in lung cancer.
Moroy G, et al.
Anticancer Agents in Medicinal Chemistry, 12, 565?579 -565?579 (2012)
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