MAK240
Factor IXa Activity Assay Kit (Fluorometric)
sufficient for 100 fluorometric tests
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About This Item
NACRES:
NA.84
UNSPSC Code:
12352200
detection method
fluorometric
relevant disease(s)
hematological disorder
storage temp.
−20°C
General description
The coagulation Factor IX (or Christmas factor) (EC 3.4.21.22) is a vitamin K-dependent serine protease. Factor IX is produced as an inactive precursor and is activated via cleavage by either factor XIa (contact pathway) or factor VIIa (tissue factor pathway). In the presence of calcium ions and negatively charged membrane phospholipids, activated factor IX (FIXa) then binds to the activated Factor VIII (FVIIIa) and proteolytically activates factor X (FX) to factor Xa (FXa). Deficiency in factor IX causes hemophilia B, an X-linked bleeding disorder.
Application
Suitable to determine the activity of purified Factor IX and to detect the activity of Factor IX in plasma and serum.
Biochem/physiol Actions
This Factor IXa Activity Assay kit is based on the ability of FIXa to generate FXa. The generated FXa proteolytically cleaves a synthetic substrate and releases a fluorophore, AMC, which can be easily quantified by fluorescence microplate reader. The assay is simple, rapid, and can detect activity as low as 10 pg of FIXa in a variety of samples.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Adenovirus-associated virus vector--mediated gene transfer in hemophilia B
Nathwani A C. et al.
The New England Journal of Medicine, 365(25), 2357-2365 (2011)
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