MAK294
MMP-3 Inhibitor Screening Kit (Fluorometric)
sufficient for 100 fluorometric tests
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About This Item
NACRES:
NA.25
UNSPSC Code:
12352200
detection method
fluorometric
relevant disease(s)
cancer
storage temp.
−20°C
General description
The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Similar to several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including Ecadherin, a known contributor to cancer development.
Application
Suitable to screen inhibitors of MMP-3.
Biochem/physiol Actions
In the MMP-3 Inhibitor Screening Assay Kit, MMP-3 hydrolyzes a specific FRET substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically ( λex = 325nm/λem = 393nm). The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of MMP-3 inhibition.
Features and Benefits
Compatible with high-throughput handling systems.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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