Merck
CN
All Photos(4)

MAK358

Sigma-Aldrich

Lithium Assay Kit

sufficient for 100 colorimetric tests

Sign Into View Organizational & Contract Pricing

Select a Size

Change View

usage

sufficient for 100 colorimetric tests

detection method

fluorometric

storage temp.

−20°C

General description

Lithium, the lightest alkali metal element, is a ductile, reactive metal that occurs in nature as the Li+ cation and is found in various mineral compounds. Physiologically, lithium is present only in trace levels and is not considered to be an essential dietary nutrient. However, lithium is routinely used in medicine as a psychoactive drug. Lithium acts as a mood stabilizer and is considered to be the gold standard first-line treatment for bipolar depression and acute mania. Patients treated with lithium are less likely to require hospitalization or complete suicide than patients treated with other mood stabilizers or antipsychotics. Chemically, lithium is the simplest possible drug—as an element, it is not metabolized by the body and has zero-order renal elimination kinetics. Lithium has a narrow therapeutic/toxic ratio and requires blood level monitoring, both to ensure efficacy and decrease the risk of toxic side-effects. The target serum concentration for lithium maintenance therapy ranges from 0.6 - 1.2 mM. At serum levels ≥1.5 mM there is a sharp increase in severe adverse effects. Overt, potentially fatal side effects (such as seizures, ataxia and loss of consciousness) are observed at serum levels >2.5 mM.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the determination of lithium concentration in biological samples such as serum and plasma. 

Principle

The Lithium Assay Kit allows for quantification of lithium levels in biological fluids such as serum and plasma. The assay uses a lithium selective bichromatic probe that undergoes an absorbance change at two distinct wavelengths upon binding to Li+ (λ1 = A540 nm, λ2 = A630 nm). The ratio of the two optical measurements is used to accurately calculate sample Li+ concentration. The kit also includes a sodium masking reagent to prevent the possibility of interference by supra-physiological levels of serum Na+ (hypernatremia). The assay is quick, is high-throughput adaptable and has a linear range from 0.5 – 10 nmole lithium per well (corresponding to 0.1 – 2 mM serum lithium).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service