usage
100 fluorometric tests
application(s)
pharmaceutical
detection method
fluorometric
relevant disease(s)
immunological diseases; cardiovascular diseases; genitourinary disorders; pulmonary disorders
storage temp.
−20°C
General description
Angiotensin II converting enzyme (ACE2), a zinc-based metalloprotease is part of the renin-angiotensin system (RAS) that controls the regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of lung, kidney and heart. ACE2 is a potential therapeutic target for cardiovascular and coronavirus-induced diseases.
Application
The kit is suitable for the detection of ACE2 activity in tissue (for example lung, heart and kidney) and overexpressed ACE2 in cell lysates, as well as the determination of enzymatic activity of purified ACE2.
Biochem/physiol Actions
The Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. An ACE2 specific inhibitor is also provided that can differentiate the ACE2 activity from other proteolytic activity. The kit is simple to use, can detect ACE2 concentrations as low as 0.4 mU.
Features and Benefits
The Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit is compatible with high-throughput handling systems.
Other Notes
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Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
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