N0290
Nitazoxanide
≥98% (HPLC), pyruvate-ferredoxin oxidoreductase (PFOR) inhibitor, powder
Synonym(s):
NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
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About This Item
Empirical Formula (Hill Notation):
C12H9N3O5S
CAS Number:
Molecular Weight:
307.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
259-931-8
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Nitazoxanide, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
originator
Romark
storage temp.
2-8°C
SMILES string
CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
InChI
1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
InChI key
YQNQNVDNTFHQSW-UHFFFAOYSA-N
General description
Nitazoxanide (NTZ), a thiazolide compound is a antiparasitic drug with structure similar to niclosamide.
Application
Nitazoxanide has been used:
- to test its anti-viral activity against chikungunya virus
- as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines
- to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells
Biochem/physiol Actions
Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria. It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies. NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV). It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria.
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
Features and Benefits
This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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