N0659
Noxiustoxin
≥95% (HPLC), recombinant, expressed in E. coli, lyophilized powder
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About This Item
UNSPSC Code:
12352200
MDL number:
mol wt
4195 Da
recombinant
expressed in E. coli
assay
≥95% (HPLC)
form
lyophilized powder
storage temp.
−20°C
Biochem/physiol Actions
Blocks voltage-gated potassium channels.
Preparation Note
Solubilize in 10 mM Tris, pH 7.5, containing 100 mM sodium chloride, 0.1% bovine serum albumin, and 1 mM EDTA
Other Notes
Originally isolated from Heteropoda venatoria
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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S Grissmer et al.
Molecular pharmacology, 45(6), 1227-1234 (1994-06-01)
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines. Kv1.1 is biophysically similar to a K+ channel in C6 glioma cells and astrocytes
E Drakopoulou et al.
Biochemical and biophysical research communications, 213(3), 901-907 (1995-08-24)
Two forms of the Centrudoides noxius scorpion noxiustoxin, containing an amidated and an acid C-terminus, were synthesized on a solid support by using Fmoc-chemistry and 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) coupling. Comparison of the two synthetic forms with the native toxin by
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