N1141
19-Nor-4-androstene-3,17-dione
Synonym(s):
4-Estrene-3,17-dione
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About This Item
Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
drug control
USDEA Schedule IIIN; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
format
neat
storage temp.
room temp
SMILES string
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CCC2=O
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1
InChI key
JRIZOGLBRPZBLQ-QXUSFIETSA-N
General description
19-Nor-4-androstene-3,17-dione is an anabolic steroid used in dietary food supplements.
Application
19-Nor-4-androstene-3,17-dione may be used as a reference standard in the determination of 19-nor-4-androstene-3,17-dione in dietary supplements using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
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Regulatory Information
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Darin van Gammeren et al.
Nutrition (Burbank, Los Angeles County, Calif.), 18(9), 734-737 (2002-09-26)
The purpose of this study was to determine the effects of norsteroid supplementation (224 mg of 19-nor-4-androstene-3,17-dione and 120 mg of 19-nor-4-androstene-3,17-diol, total daily dose = 344 mg) on body composition and strength in resistance-trained men. In a placebo-controlled, double-blind
S Frese et al.
Archives of toxicology, 85(6), 635-643 (2010-10-20)
Both 19-norandrostenedione (estr-4-ene-3,17-dione, NOR) and desoxymethyltestosterone (17alpha-methyl-5alpha-androst-2-en-17beta-ol, DMT or "madol") are 'designer steroids' misused for doping purposes in the bodybuilding scene. We have previously characterized the pharmacological profile of madol and identified potential adverse side effects. The aim of this
P Diel et al.
Toxicology letters, 177(3), 198-204 (2008-03-08)
One of the most frequently misused steroid precursors (prohormones) is 19-norandrostenedione (4-estrene-3,17-dione, NOR), which is, after oral administration, readily metabolised to nortestosterone, also known as nandrolone (durabolin). In this study we have characterised molecular mechanisms of its action determined its
L Dehennin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 766(2), 257-263 (2002-02-05)
The dietary supplements 19-norandrostenedione and 19-norandrostenediol are potential metabolic precursors of nandrolone. They are considered by law in the United States as prohormones without proven therapeutic, curative or diagnostic properties, and therefore available as over-the-counter drugs. Oral dosages of 0.1-1
Ying Lung Tseng et al.
Journal of analytical toxicology, 29(2), 124-134 (2005-05-21)
Nandrolone is one of the synthetic anabolic steroids banned in sports and has been a popular substance abused by athletes in recent years. One of its major metabolites, 19-norandrosterone (19-NA), has been used as a determinant for drug violations in
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