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N1162

NS3763

Name: NS3763
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

5-Carboxy-2,4-dibenzamidobenzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₆N₂O₆

CAS Number:

70553-45-6

Molecular Weight:

404.37

NACRES:

NA.77

PubChem Substance ID:

24724545

UNSPSC Code:

12352202

MDL number:

MFCD00334657

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~24 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3

InChI

1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)

InChI key

UUDYZUDTQPLDDP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

First non-competitive antagonist of GluK5 receptor.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number

025K4606

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Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53.

Katherine Waters et al.

Developmental biology, 344(2), 1011-1025 (2010-07-06)

Proliferating germ cells in Caenorhabditiselegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling, we identified approximately 200 genes upregulated in the proliferating germ cells of C. elegans. Functional

Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.

Péter Erdélyi et al.

Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)

Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the important developmental and medical

MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.

Saravanapriah Nadarajan et al.

Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)

Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for

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Global Trade Item Number

SKU	GTIN
N1162-5MG	04061832083346