N1162
NS3763
≥98% (HPLC), solid
Synonym(s):
5-Carboxy-2,4-dibenzamidobenzoic acid
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About This Item
Empirical Formula (Hill Notation):
C22H16N2O6
CAS Number:
Molecular Weight:
404.37
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: ~24 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3
InChI
1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
InChI key
UUDYZUDTQPLDDP-UHFFFAOYSA-N
Biochem/physiol Actions
First non-competitive antagonist of GluK5 receptor.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)
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Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)
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RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model
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The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been
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