N139
(−)-Normetazocine
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About This Item
Empirical Formula (Hill Notation):
C14H19NO
CAS Number:
Molecular Weight:
217.31
UNSPSC Code:
41116107
MDL number:
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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S W Mascarella et al.
Journal of medicinal chemistry, 38(3), 565-569 (1995-02-03)
sigma 1 receptor ligands have potential pharmacological significance as antipsychotic drugs, as tools in the study of drug-induced motor function disorders, and as radiopharmaceutical imaging agents for the noninvasive imaging of malignant tumors in human subjects. A series of substituted
B de Costa et al.
Journal of medicinal chemistry, 35(12), 2221-2230 (1992-06-12)
Unlabeled fluoro- and iodo-substituted ligands exhibiting very high affinity and selectivity for sigma receptors were synthesized based on three different structural classes of sigma receptor ligands. These compounds were evaluated for sigma receptor affinity and specificity in order to assess
Multiple opioid receptors.
E T Iwamoto et al.
Medicinal research reviews, 1(4), 411-440 (1981-01-01)
M D Aceto et al.
Journal of pharmaceutical sciences, 73(12), 1864-1866 (1984-12-01)
alpha-(-)-, (+)-, and (+/-)-N-4-Methylpentyl-, (-)- and (+)-N-cis-3-chloroallyl-, and (-)- and (+)-N-propynyl-N-normetazocine (I, II, and III, respectively) have been prepared from alpha-(-)-, (+)-, and (+/-)-N-normetazocine (IV) and tested for antinociceptive activity in mice and in morphine-dependent rhesus monkeys. The results obtained
R Danso-Danquah et al.
Journal of medicinal chemistry, 38(15), 2986-2989 (1995-07-21)
The synthesis and sigma 1 and sigma 2 binding properties of several 1'- and 3'-halo- and 1',3'-dihalo-substituted analogues of (+)-N-benzyl- and (+)- and (-)-N-dimethylallyl-N-normetazocine are presented. Structure-activity relationship analyses of the binding data showed that halogen substitution at the 1'-position
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