N145
[Lys5, MeLeu9, Nle10]-α-Neurokinin Fragment 4-10
>98%
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About This Item
Empirical Formula (Hill Notation):
C39H64N8O10
Molecular Weight:
804.97
UNSPSC Code:
12352200
MDL number:
SMILES string
CCCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(O)=O
assay
>98%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TAC1(6863)
Biochem/physiol Actions
Potent NK-2 tachykinin receptor agonist.
Regulatory Information
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J L Black et al.
British journal of pharmacology, 107(2), 429-436 (1992-10-01)
1. In many species, both NK1 and NK2 tachykinin receptors appear to be important in mediating the contraction of airway smooth muscle. We have examined the distribution and characterization of receptors for tachykinins in rabbit airways using functional length tension
L Fisher et al.
Regulatory peptides, 46(1-2), 396-398 (1993-07-02)
Tachykinin receptors mediating uterotonic effects were examined in preparations from oestrogen-primed rats. In the absence of peptidase inhibitors [Lys5-MeLeu9-Nle10] NKA (4-10) was 14-fold more potent than neurokinin A (NKA), but the two peptides were equipotent in the presence of phosphoramidon
G Chassaing et al.
Neuropeptides, 19(2), 91-95 (1991-06-01)
All the synthetized NKA and NKA (4-10) agonists have been found active in the rat portal vein bioassay. Even [Lys5, MeLeu9, Nle10] NKA(4-10), a highly potent competitor of NK-2 binding sites with very low binding potencies for NK-1 and NK-3
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