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N158

Naftopidil hydrochloride hydrate

solid

Synonym(s):

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611

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About This Item

Empirical Formula (Hill Notation):
C24H28N2O3 · xHCl · yH2O
CAS Number:
57149-07-2
Molecular Weight:
392.49 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
24277790
UNSPSC Code:
12352200
MDL number:
MFCD11046013
Form:
solid
Quality level:
200
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form

solid

Quality Level

200

color

white

solubility

methanol: >10 mg/mL, H2O: insoluble

SMILES string

O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34

InChI

1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2

InChI key

INIDYCYXDNFBSV-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Biochem/physiol Actions

α1-Adrenoceptor antagonist; antihypertensive.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000329566
0000329583
0000329583
0000329566
SLCM9335

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Yasuo Tsuzaka et al.
International journal of urology : official journal of the Japanese Urological Association, 18(11), 792-795 (2011-09-16)
The aim of the present study was to compare the efficacy of the selective α(1D) -adrenoceptor antagonist naftopidil and the selective α(1A) -adrenoceptor antagonist silodosin (as an example) in the management of ureteral stones in Japanese male patients. A total
S Yamada et al.
Life sciences, 50(2), 127-135 (1992-01-01)
Binding properties of naftopidil and alpha 1-adrenoceptor antagonists to alpha-adrenoceptors in prostates from benign prostatic hypertrophy (BPH) were characterized by radioreceptor assays using [3H]prazosin and [3H]rauwolscine. Specific binding of [3H]prazosin and [3H]rauwolscine in human prostatic membranes was saturable and of
G Sponer et al.
Journal of cardiovascular pharmacology, 20(6), 1006-1013 (1992-12-01)
The interaction of naftopidil with adrenoceptors was studied in comparison to standard drugs. Naftopidil binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil
Hideyasu Tsumura et al.
International journal of radiation oncology, biology, physics, 81(4), e385-e392 (2011-06-15)
To compare the efficacy of three α(1A)/α(1D)-adrenoceptor (AR) antagonists--naftopidil, tamsulosin, and silodosin--that have differing affinities for the α(1)-AR subtypes in treating urinary morbidities in Japanese men with (125)I prostate implantation (PI) for prostate cancer. This single-institution prospective randomized controlled trial
Tomokazu Sazuka et al.
Journal of endourology, 26(9), 1216-1220 (2012-04-11)
To examine the efficacy of an alpha-1 blocker and its correlation to structural alteration of the prostatic urethra and the loss of energy in the urine flow using a virtual urethra processed from an endoscopic video image. Video images of
View All Related Papers

Global Trade Item Number

SKUGTIN
N158-100MG04061832092218
N158-25MG04061832092225

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