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Merck
CN

N190

[D-Tyr27,36, D-Thr32]-Neuropeptide Y fragment 27-36, rat

>97%, lyophilized powder

Synonym(s):

[D-Tyr27,36, D-Thr32]-NPY Fragment 27-36, rat, D-Tyr-Ile-Asn-Leu-Ile-D-Thr-Arg-Gln-Arg-D-Tyr-NH2

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About This Item

Empirical Formula (Hill Notation):
C61H98N19O15
Molecular Weight:
1337.55
UNSPSC Code:
12352202
PubChem Substance ID:
329818592
MDL number:
MFCD00672464

Key Documents

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InChI

1S/C61H99N19O15/c1-8-31(5)47(78-51(87)38(62)27-34-14-18-36(82)19-15-34)57(93)77-44(29-46(64)85)55(91)76-43(26-30(3)4)56(92)79-48(32(6)9-2)58(94)80-49(33(7)81)59(95)74-40(13-11-25-71-61(68)69)52(88)73-41(22-23-45(63)84)54(90)72-39(12-10-24-70-60(66)67)53(89)75-42(50(65)86)28-35-16-20-37(83)21-17-35/h14-21,30-33,38-44,47-49,81-83H,8-13,22-29,62H2,1-7H3,(H2,63,84)(H2,64,85)(H2,65,86)(H,72,90)(H,73,88)(H,74,95)(H,75,89)(H,76,91)(H,77,93)(H,78,87)(H,79,92)(H,80,94)(H4,66,67,70)(H4,68,69,71)/t31-,32-,33-,38+,39-,40-,41-,42+,43-,44-,47-,48-,49+/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O

InChI key

ZSPXOUGXONWRQC-FHDPKJCZSA-N

assay

>97%

form

lyophilized powder

color

white

storage temp.

−20°C

Biochem/physiol Actions

[D-Tyr27,36, D-Thr32]-Neuropeptide Y fragment 27-36, rat is neurotransmitter.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122K1306
073K1314
110K1198

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Neuronal and non-neuronal modulation of sympathetic neurovascular transmission
Macarthur, H.
Acta Physiol., 203, 37-45 (2011)
J M VanNess et al.
Brain research, 821(2), 263-269 (1999-03-05)
We hypothesized that hypothalamic NPYergic mechanisms mediate the blood pressure lowering effect of caloric restriction in hypertensive rats. Aortic coarctation-induced (AC) hypertensive rats (n=25) were assigned to either an ad libitum fed control group (AL) or food restricted group (FR;
R D Myers et al.
Brain research bulletin, 37(3), 237-245 (1995-01-01)
Neuropeptide Y (NPY) produces a vigorous feeding response in several species when it is injected into hypothalamic structures involved in eating behavior. The purpose of this study was to determine whether a unique carboxy terminal fragment of NPY would alter

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