N2034
CR 2249
Synonym(s):
(S)-4-Amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxopentanoic acid, Nebostinel
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About This Item
Empirical Formula (Hill Notation):
C13H24N2O3
CAS Number:
Molecular Weight:
256.34
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C13H24N2O3/c1-13(2)7-5-9(6-8-13)15-12(18)10(14)3-4-11(16)17/h9-10H,3-8,14H2,1-2H3,(H,15,18)(H,16,17)/t10-/m0/s1
SMILES string
CC1(C)CCC(CC1)NC(=O)[C@@H](N)CCC(O)=O
InChI key
VCRGLZYPNNAVRP-JTQLQIEISA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)
Biochem/physiol Actions
Facilitates glycine action at NMDA glutamate receptors; may identify a separate allosteric modulatory site on the NMDA receptor; putative cognition enhancer.
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M Lanza et al.
Neuropharmacology, 36(8), 1057-1064 (1997-08-01)
The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-mediated reversion of kynurenate antagonism at
A Pittaluga et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 423-428 (1999-06-25)
Some cognition enhancers were previously shown to potently prevent antagonism of the N-methyl-D-aspartate (NMDA)-evoked release of norepinephrine (NE) brought about in slices of rat hippocampus by kynurenic acid, an endogenous NMDA receptor blocker. We have examined the impact of putative
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