N2287
N744 tosylate
≥90% (HPLC), solid
Synonym(s):
3-(2-Hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5-methoxy-2-benzothiazolylidene]methyl]-1-butenyl]-5-methoxybenzothiazolium tosylate
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About This Item
Empirical Formula (Hill Notation):
C25H29N2O4S2 · C7H7O3S
CAS Number:
Molecular Weight:
656.83
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CCC(\C=C2/Sc3ccc(OC)cc3N2CCO)=C/c4sc5ccc(OC)cc5[n+]4CCO
assay
≥90% (HPLC)
form
solid
storage condition
protect from light
color
purple/blue
solubility
DMSO: ~10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Inhibitor of tau aggregation.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Carmen Chirita et al.
Biochemistry, 43(10), 2879-2887 (2004-03-10)
Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments comprised of the microtubule associated protein tau. Because animal model studies suggest that a toxic gain of function accompanies tau aggregation in neurons, selective pharmacological inhibitors of the
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