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N2390

19-Norprogesterone

powder

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About This Item

Empirical Formula (Hill Notation):
C20H28O2
CAS Number:
472-54-8
Molecular Weight:
300.44
UNSPSC Code:
12352202
PubChem Substance ID:
24897571
MDL number:
MFCD00058412
Form:
powder
Assay:
≥98% (TLC)
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assay

≥98% (TLC)

form

powder

color

off-white

solubility

chloroform: 50 mg/mL, clear to slightly hazy, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@]12CCC(=O)C=C1CC[C@]3([H])[C@]2([H])CC[C@]4(C)[C@H](CC[C@@]34[H])C(C)=O

InChI

1S/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1

InChI key

NVUUMOOKVFONOM-GPBSYSOESA-N

Gene Information

human ... SERPINA6(866)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
MKCB0900V
MKBQ3270V
SLBB9128V
081M1653V
071M1371V

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J Botella et al.
Journal of endocrinological investigation, 13(11), 905-910 (1990-12-01)
19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR). In contrast, 17 alpha-hydroxylated-progesterone (17OHP) shows no hormonal activity and does not compete with progesterone (P) for the PgR. The aim of the present
J C Melby et al.
Clinical and experimental hypertension. Part A, Theory and practice, 4(9-10), 1851-1867 (1982-01-01)
Recent reports demonstrate that the 19-nor-corticosteroids (19-nor-DOC) are naturally-occurring substances in hypertensive animal models as well as man. Since some 19-nor-corticosteroids are potent mineralocorticoids, they may have a role in regulating systemic arterial pressure and be involved in the pathogenesis
Xiangyan Ruan et al.
Maturitas, 71(4), 345-353 (2012-03-01)
Nomegestrol acetate (NOMAC) is a 19-norprogesterone derivative with high biological activity at the progesterone receptor, a weak anti-androgenic effect, but with no binding to estrogen, glucocorticoid or mineralocorticoid receptors. At dosages of 1.5mg/day or more, NOMAC effectively suppresses gonadotropic activity
J Botella et al.
The Journal of steroid biochemistry and molecular biology, 55(1), 77-84 (1995-10-01)
Estrogen receptors of human endometrial cancer Ishikawa cells were found to be present in moderate amounts (160-200 fmol/mg protein), and to specifically bind moxestrol (R2858) with a very high affinity characterized by a Kd around 60 pM, when measured under
M J Schiff et al.
Endocrinology, 115(4), 1235-1238 (1984-10-01)
19-Nor-corticosteroids are potentially important mineralocorticoids and hypertensive agents. We tested the mineralocorticoid potency of 19-nor-progesterone (19-NOR-P) and 19-nor-corticosterone (19-NOR-B) compared with aldosterone using the toad bladder short-circuit current as a measure of sodium transport. 19-NOR-B (10(-7) M) increased sodium transport
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