N2390
19-Norprogesterone
powder
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About This Item
Empirical Formula (Hill Notation):
C20H28O2
CAS Number:
Molecular Weight:
300.44
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Form:
powder
Assay:
≥98% (TLC)
assay
≥98% (TLC)
form
powder
color
off-white
solubility
chloroform: 50 mg/mL, clear to slightly hazy, colorless to light yellow
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@]12CCC(=O)C=C1CC[C@]3([H])[C@]2([H])CC[C@]4(C)[C@H](CC[C@@]34[H])C(C)=O
InChI
1S/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1
InChI key
NVUUMOOKVFONOM-GPBSYSOESA-N
Gene Information
human ... SERPINA6(866)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J Botella et al.
Journal of endocrinological investigation, 13(11), 905-910 (1990-12-01)
19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR). In contrast, 17 alpha-hydroxylated-progesterone (17OHP) shows no hormonal activity and does not compete with progesterone (P) for the PgR. The aim of the present
J C Melby et al.
Clinical and experimental hypertension. Part A, Theory and practice, 4(9-10), 1851-1867 (1982-01-01)
Recent reports demonstrate that the 19-nor-corticosteroids (19-nor-DOC) are naturally-occurring substances in hypertensive animal models as well as man. Since some 19-nor-corticosteroids are potent mineralocorticoids, they may have a role in regulating systemic arterial pressure and be involved in the pathogenesis
Xiangyan Ruan et al.
Maturitas, 71(4), 345-353 (2012-03-01)
Nomegestrol acetate (NOMAC) is a 19-norprogesterone derivative with high biological activity at the progesterone receptor, a weak anti-androgenic effect, but with no binding to estrogen, glucocorticoid or mineralocorticoid receptors. At dosages of 1.5mg/day or more, NOMAC effectively suppresses gonadotropic activity