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Merck
CN

N3385

Sigma-Aldrich

N-Nitroso-N-ethylurea

ISOPAC®

Synonym(s):

ENU, N-Ethyl-N-nitrosourea

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About This Item

Empirical Formula (Hill Notation):
C3H7N3O2
CAS Number:
759-73-9
Molecular Weight:
117.11
EC Number:
212-072-2
MDL number:
MFCD00053635
UNSPSC Code:
12352102
PubChem Substance ID:
24897640
NACRES:
NA.25

Key Documents

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Quality Level

100

form

powder

storage temp.

−20°C

SMILES string

CCN(N=O)C(N)=O

InChI

1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

InChI key

FUSGACRLAFQQRL-UHFFFAOYSA-N

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Application

N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Packaging

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
1 vial contains 1 g of material calculated on anhydrous basis.

Preparation Note

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8727
MKCV0567
MKCT1606
MKCR6942
MKCN4387

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Mouse mutagenesis using N-ethyl-N-nitrosourea (ENU).
Salinger AP and Justice MJ
Cold Spring Harbor Protocols, 4 (2008)
Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant.
Biehlmaier O, et al.
Investigative Ophthalmology & Visual Science, 44, 1287-1287 (2003)
Induction of mutations by ENU in the medaka germline.
Ishikawa Y
The fish biology journal Medaka, 10, 27-29 (1999)
Sukalpa Chattopadhyay et al.
Journal of cell communication and signaling, 13(1), 39-52 (2018-07-07)
The evolutionarily conserved Wnt signaling pathway regulates physiological hematopoiesis, a process of formation of blood cells and has been shown to play crucial role in the development of both myeloid and lymphoid malignancies. The Wnt signaling pathway can be broadly
Daniel R Beisner et al.
The Journal of experimental medicine, 210(1), 23-30 (2012-12-26)
B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early
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Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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