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Safety Information

N3510

Sigma-Aldrich

Niclosamide

Synonym(s):

2′,5-Dichloro-4′-nitrosalicylanilide

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25 MG
¥457.29
100 MG
¥1,259.43
250 MG
¥3,523.85
1 G
¥10,588.34

¥457.29

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25 MG
¥457.29
100 MG
¥1,259.43
250 MG
¥3,523.85
1 G
¥10,588.34

About This Item

Empirical Formula (Hill Notation):
C13H8Cl2N2O4
CAS Number:
50-65-7
Molecular Weight:
327.12
Beilstein:
2820605
EC Number:
200-056-8
MDL number:
MFCD00057597
UNSPSC Code:
51102829
PubChem Substance ID:
24278585
NACRES:
NA.85

¥457.29

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form

powder

Quality Level

200

antibiotic activity spectrum

parasites

Mode of action

enzyme | inhibits

SMILES string

Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O

InChI

1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChI key

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

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(S)-(+)-2-(氨甲基)吡咯烷 97%

422886

(S)-(+)-2-(氨甲基)吡咯烷

(S)-(+)-2-(三氟甲基)吡咯烷 97%

665614

(S)-(+)-2-(三氟甲基)吡咯烷

4-(2-氨基)苯乙胺 97%

123056

4-(2-氨基)苯乙胺

(S)-3-(Aminomethyl)-1-Boc-pyrrolidine 95%

689823

(S)-3-(Aminomethyl)-1-Boc-pyrrolidine

assay

97%

assay

97%

assay

97%

assay

≥95.0% (HPLC), 95%

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

bp

65 °C/11 mmHg (lit.)

bp

-

bp

103 °C/0.3 mmHg (lit.)

bp

-

form

liquid

form

solid

form

-

form

liquid

refractive index

n20/D 1.482 (lit.)

refractive index

-

refractive index

n20/D 1.591 (lit.)

refractive index

-

density

0.933 g/mL at 25 °C (lit.)

density

-

density

1.034 g/mL at 25 °C (lit.)

density

-

Application

Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells[1].

Biochem/physiol Actions

Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.

Other Notes

50g,250g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000453974
    0000453974
    0000359873
    0000359872
    0000359873

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