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Merck
CN

N3762

Neuromedin B

≥90% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C52H73N15O12S
CAS Number:
87096-84-2
Molecular Weight:
1132.29
NACRES:
NA.77
PubChem Substance ID:
24897661
UNSPSC Code:
12352200
MDL number:
MFCD00167607

Key Documents

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InChI

1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)

SMILES string

CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O

InChI key

YPFNACALNKVZNK-UHFFFAOYSA-N

assay

≥90% (HPLC)

form

powder

storage temp.

−20°C

Quality Level

100

General description

Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.

Application

Neuromedin B (NMB) has been used as a bombesin (BN)-like peptide:
  • for injection in mice to understand energy expenditure and oxygen consumption and CO2 production
  • to study its effects on the thyrotropin (TSH) and prolactin (PRL) release in vitro
  • to analyze its effects on angiogenesis through the activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in endothelial cells

Biochem/physiol Actions

Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.

Features and Benefits

This compound is featured on the Bombesin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6980
MKCW9749
MKCN3556
MKCL8609
MKCG8512

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Cheryl D Stimpson et al.
American journal of human biology : the official journal of the Human Biology Council, 23(1), 22-28 (2010-12-09)
Von Economo neurons (VENs) are defined by their thin, elongated cell body and long dendrites projecting from apical and basal ends. These distinctive neurons are mostly present in anterior cingulate (ACC) and fronto-insular (FI) cortex, with particularly high densities in
J M Siegfried et al.
Pulmonary pharmacology & therapeutics, 12(5), 291-302 (1999-11-05)
Gastrin-releasing peptide (GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion. In this report, we demonstrate that
Z Merali et al.
Behavioural brain research, 198(1), 105-112 (2008-11-19)
Repeated exposure to stressors was reported to increase the expression of arginine-vasopressin (AVP), especially in corticotropin-releasing hormone (CRH) neurons co-expressing AVP, within the hypothalamus. This may increase the potential for subsequent stressor-elicited enhancement of hypothalamic-pituitary-adrenal (HPA) functioning as these peptides
H Ohki-Hamazaki
Progress in neurobiology, 62(3), 297-312 (2000-06-07)
Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals. It was originally purified from pig spinal cords, and it has been shown to be present in central nervous system as well as in gastrointestinal tract. BN and
L E Heasley
Oncogene, 20(13), 1563-1569 (2001-04-21)
Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. In addition to polypeptide growth factors such as EGF family members which signal through receptor tyrosine kinases, accumulating evidence supports the autocrine
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