N4786
NPS 2390
≥99% (HPLC), solid
Synonym(s):
Quinoxaline-2-carboxylic acid adamantan-1-ylamide
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About This Item
Empirical Formula (Hill Notation):
C19H21ON3
CAS Number:
Molecular Weight:
307.39
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
description
Caution-Not Yet Fully Tested-For Research Use Only-Not For Human Use.
assay
≥99% (HPLC)
form
solid
color
white
solubility
DMSO: soluble ~5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C(NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2)c4cnc5ccccc5n4
InChI
1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)/t12-,13+,14-,19-
InChI key
ZKFVOZCCAXQXBU-KRFSREQESA-N
Biochem/physiol Actions
Type I metabotropic glutamate receptor antagonist
Legal Information
Sold with the permission of NPS Pharmaceuticals, Inc. striclty for in vitro use only.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonist.
Van Wagenen, B.C., et al.
Abstr. Soc. Neurosci, #618.3 (2000)
Nicola Antonio Martino et al.
PloS one, 6(3), e17714-e17714 (2011-03-26)
The present study investigates the effects of high external calcium concentration ([Ca(2+)](o)) and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines. The involvement of
Charalambos Kaittanis et al.
The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in