N5135
Normorphine hydrochloride monohydrate
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About This Item
Empirical Formula (Hill Notation):
C16H17NO3 · HCl · H2O
CAS Number:
Molecular Weight:
325.79
EC Number:
222-152-9
UNSPSC Code:
41116107
drug control
USDEA Schedule I; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada, kontrollierte Droge in Deutschland
Biochem/physiol Actions
Narcotic analgesic
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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F Porreca et al.
The Journal of pharmacology and experimental therapeutics, 225(3), 688-693 (1983-06-01)
The affinity of normorphine for its pharmacologic receptor was determined using the longitudinal muscle-myenteric plexus preparation of naive and morphine-tolerant guinea pigs and the method of partial blockade of a fraction of the receptor population with the novel, irreversible opiate
M Pawula et al.
Journal of pharmaceutical and biomedical analysis, 11(4-5), 401-406 (1993-04-01)
A new, simple and rapid extraction procedure coupled with a combined coulometric-fluorescence HPLC assay is described for the simultaneous determination of morphine (M) and morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and normorphine (NM) in plasma. The effect of concentration and pH of
J Hasselström et al.
Pharmacology & toxicology, 79(1), 40-46 (1996-07-01)
Morphine, morphine-6-glucuronide and normorphine were administered to male Sprague-Dawley-rats. Analgesic effect was estimated with the hot plate and spinal nociceptive reflex depression. After intraperitoneal administration the molar potency ratio of morphine-6-glucuronide/morphine was 1.7 estimated by the paw lick latency on
A A Coutts et al.
Canadian journal of physiology and pharmacology, 76(3), 340-346 (1998-07-23)
Cannabinoid receptor agonists inhibit electrically evoked isometric contractions of the myenteric plexus--longitudinal muscle preparation of the guinea-pig small intestine (MPLM), probably by reducing release of acetylcholine (ACh) through the activation of prejunctional CB1 receptors. As CB1 receptors are thought to
O Dale et al.
European journal of clinical pharmacology, 63(9), 837-842 (2007-07-11)
To compare the time course of morphine and metabolite concentrations in serum and cerebrospinal fluid (CSF) after intravenous and intramuscular administration after surgery. This was a randomized double-blind, double-dummy study in patients who had undergone hip replacement surgery. Morphine (M
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