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Merck
CN

N5770

Sigma-Aldrich

Nalmefene

Synonym(s):

(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol

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About This Item

Empirical Formula (Hill Notation):
C21H25NO3
CAS Number:
55096-26-9
Molecular Weight:
339.43
MDL number:
MFCD00133650
UNSPSC Code:
12352200
PubChem Substance ID:
24897753

Key Documents

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form

solid

originator

Baxter

storage temp.

2-8°C

SMILES string

Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=C)CC[C@@]35O)CC6CC6

InChI

1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

InChI key

WJBLNOPPDWQMCH-MBPVOVBZSA-N

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprd1(24613), Oprm1(25601)

Biochem/physiol Actions

Nonselective opioid receptor antagonist.

Features and Benefits

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H336,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
070M4045V
038K4109
038K4066
103K4133
071K4085

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Jon E Grant et al.
Psychopharmacology, 200(4), 521-527 (2008-06-27)
Although opiate antagonists have shown promise in the treatment of pathological gambling (PG), individual responses vary. No studies have systematically examined predictors of medication treatment outcome in PG. Understanding clinical variables related to treatment outcome should help generate treatment algorithms
Stephani A Day et al.
Biochemical pharmacology, 81(8), 996-1003 (2011-02-05)
Hepatic fibrosis is characterized by excess type I collagen deposition and exacerbated inflammatory response. Naltrexone, an opioid receptor antagonist used for treating alcohol abuse, attenuates hepatocellular injury in fibrotic animal models, which can be accompanied by deleterious side effects. Additionally
Susanne Rösner et al.
The Cochrane database of systematic reviews, (12)(12), CD001867-CD001867 (2010-12-15)
Alcohol dependence belongs to the globally leading health risk factors. Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene. To determine the effectiveness and
Trial watch: Nalmefene reduces alcohol use in phase III trial.
Nature reviews. Drug discovery, 10(8), 566-566 (2011-08-02)
Rainer Spanagel et al.
Current topics in behavioral neurosciences, 13, 583-609 (2012-03-06)
Here we discuss treatment strategies that are based on pharmacological interventions to reduce craving and relapse in alcohol-dependent patients. We will first provide a historical overview about relapse prevention strategies. We will then review the development of disulfiram, naltrexone, acamprosate
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