N6007
1-Nitrosopiperidine
Synonym(s):
NPIP
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About This Item
Empirical Formula (Hill Notation):
C5H10N2O
CAS Number:
Molecular Weight:
114.15
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
202-886-6
MDL number:
SMILES string
O=NN1CCCCC1
density
1.06 g/mL (lit.)
storage temp.
2-8°C
Biochem/physiol Actions
Carcinogen that induces benign and malignant tumors of the respiratory tract, stomach and esophagus in rodents; potent nasal carcinogen in rats.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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P Levallois et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 38(11), 1013-1019 (2000-10-19)
Urinary excretion of volatile nitrosamines was assessed in 59 non-smokers living in a rural county of Québec, Canada. Water and food intakes were measured by means of a 24-hour recall. Nitrates were analyzed in the tap water of all participants
Y Yamashita et al.
Mutation research, 348(4), 163-168 (1995-12-01)
N-Nitrosodialkylamines are promutagens and proclastogens, requiring metabolic activation for their actions. Previously, we showed that direct-acting bacterial mutagens can be formed from N-nitrosodialkylamines on exposure to near-UV. We have now found that N-nitrosodialkylamines with near-UV irradiation are clastogenic to Chinese
I T Vermeer et al.
Mutation research, 428(1-2), 353-361 (1999-10-13)
Many constituents present in the human diet may inhibit endogenous formation of N-nitroso compounds (NOC). Studies with human volunteers showed inhibiting effects of intake of ascorbic acid and green tea consumption on nitrosation using the N-nitrosoproline test. The aim of
Almudena García et al.
Cell biology international, 33(12), 1280-1286 (2009-09-15)
The human hepatoma cell line (HepG2) exhibited a dose and time-dependent apoptotic response following treatment with N-Nitrosopiperidine (NPIP) and N-Nitrosodibutylamine (NDBA), two recognized human carcinogens. Our results showed a significant apoptotic cell death (95%) after 24h treatment with NDBA (3.5
Samuel González-Mancebo et al.
Mutation research, 558(1-2), 45-51 (2004-03-24)
The genotoxicity of nitrosopiperidine and six alkyl derivatives was studied by use of the Ames tester strains TA100 and TA1535 in the pre-incubation method. Among the compounds investigated, those exhibiting genotoxic activity under the experimental conditions employed were only genotoxic
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