N7001
2-Nitro-4-carboxyphenyl N,N-diphenylcarbamate
Synonym(s):
NCDC
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About This Item
Empirical Formula (Hill Notation):
C20H14N2O6
CAS Number:
Molecular Weight:
378.33
UNSPSC Code:
12352202
MDL number:
SMILES string
OC(=O)c1ccc(OC(=O)N(c2ccccc2)c3ccccc3)c(c1)N(=O)=O
Application
Can be used for the determination of chymotrypsin; liberates 4-hydroxy-3-nitrobenzoic acid (also available from Sigma).
Biochem/physiol Actions
Specific chromogenic inactivator of chymotrypsin. Inhibits anti-IgE-mediated histamine release and inositol trisphosphate (IP3) production in mast cells, possibly by a mechanism involving inhibition of phospholipase C (PLC).
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M Takei et al.
Biochemical and biophysical research communications, 181(3), 1313-1322 (1991-12-31)
NCDC dose-dependently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Moreover, NCDC inhibited Ca(2+)-mobilization from intracellular Ca(2+)-stores as well as histamine release in mast cells activated by anti IgE, the effect on both of these phenomena being
THE UTILIZATION OF A SPECIFIC CHROMOGENIC INACTIVATOR IN AN "ALL OR NONE" ASSAY FOR CHYMOTRYPSIN.
B F ERLANGER et al.
Biochemistry, 3, 346-349 (1964-03-01)
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