N7537
NSC 663284
≥98% (HPLC), solid
Synonym(s):
6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
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About This Item
Empirical Formula (Hill Notation):
C15H16ClN3O3
CAS Number:
Molecular Weight:
321.76
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
red
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI key
BMKPVDQDJQWBPD-UHFFFAOYSA-N
Gene Information
human ... CDC25B(994), DUSP3(1845), PTPN1(5770)
Related Categories
Application
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
Biochem/physiol Actions
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
470.1 °F
Flash Point(C)
243.4 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Kizuna is a novel mitotic substrate for CDC25B phosphatase
Thomas Y, et al.
Cell Cycle, 13(24), 3867-3877 (2014)
Inhibition of DUSP13B Activity by NSC 663284
Lee I S, et al.
Bulletin of the Korean Chemical Society,, 33(10), 3505-3507 (2012)
Utility of resazurin, horseradish peroxidase, and NMR assays to identify redox-related false-positive behavior in high-throughput screens
Tarnowski M, et al.
Assay and Drug Development Technologies, 16(3), 171-191 (2018)
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