N8784
Norcantharidin
solid
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About This Item
Empirical Formula (Hill Notation):
C8H8O4
CAS Number:
Molecular Weight:
168.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
form
solid
SMILES string
O=C1OC(=O)C2C3CCC(O3)C12
InChI
1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
InChI key
JAABVEXCGCXWRR-UHFFFAOYSA-N
Gene Information
human ... PPP2R5A(5525)
General description
Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).
Application
Norcantharidin has been used in primary cell culture and treatment. It has also been used to treat mice inoculated with Huh7 cells subcutaneously.
Biochem/physiol Actions
Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
高风险级别生物产品--毒素类产品
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Mark Tarleton et al.
European journal of medicinal chemistry, 54, 573-581 (2012-07-17)
Cantharidin (1) and norcantharidin (2) display high levels of anticancer activity against a broad range of tumour cell lines. Synthetic manipulation of norcantharidin yields (3S,3aR,4S,7R,7aS)-3-hydroxyhexahydro-4,7-epoxyisobenzofuran-1(3H)-one (3), which also displays a high level of anticancer activity against tumour cells but interestingly
Xin-Yuan Ding et al.
International journal of nanomedicine, 7, 1723-1735 (2012-05-24)
A novel formulation containing polyvinylpyrrolidone (PVP) K(30)-coated norcantharidin (NCTD) chitosan nanoparticles (PVP-NCTD-NPs) was prepared by ionic gelation between chitosan and sodium tripolyphosphate. The average particle size of the PVP-NCTD-NPs produced was 140.03 ± 6.23 nm; entrapment efficiency was 56.33% ±
Min Guan et al.
International journal of nanomedicine, 7, 1921-1930 (2012-05-19)
In this paper, novel liver-targeting nanoparticles (NPs), lactosyl-norcantharidin (Lac-NCTD)-associated N-trimethyl chitosan (TMC) NPs (Lac-NCTD-TMC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, and encapsulation efficiency of the nanoparticles were then investigated. The continuous line of heterogeneous human epithelial
Yong Li et al.
Frontiers in pharmacology, 11, 187-187 (2020-03-21)
Drug repositioning, development of new uses for marketed drugs, is an effective way to discover new antitumor compounds. In this study, we used a new method, filtering compounds via molecular docking to find key targets combination. The data of gene
Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.
Yong-yan Bei et al.
International journal of nanomedicine, 7, 1819-1827 (2012-05-24)
In this paper, two novel liver-targeting nanoparticles, norcantharidin-loaded chitosan nanoparticles (NCTD-CS-NPs) and norcantharidin-associated galactosylated chitosan nanoparticles (NCTD-GC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, encapsulation efficiency, and drug release characteristics of the nanoparticles were investigated in vitro.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N8784-1G | 04061826739624 |
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