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Merck
CN

O0641

Oroxylin A

≥98% (HPLC)

Synonym(s):

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one, 5,7-Dihydroxy-6-methoxyflavone;, 6-Methoxybaicalein;

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About This Item

Empirical Formula (Hill Notation):
C16H12O5
CAS Number:
480-11-5
Molecular Weight:
284.26
UNSPSC Code:
12352200
PubChem Substance ID:
329818889
MDL number:
MFCD02259441

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InChI

1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

SMILES string

COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3

InChI key

LKOJGSWUMISDOF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

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Biochem/physiol Actions

Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. It shows amelioration of Abeta(25-35) peptide-induced memory impairment.
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administration, or by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activations, iNOS expression, lipid peroxidation, and increased cholinergic neurotransmission after subchronic administration.

signalword

Warning

pictograms

Exclamation mark
GHS07

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4605V
060M4608

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Chenrui Li et al.
The AAPS journal, 14(1), 23-34 (2011-12-15)
Radix Scutellariae is a commonly used herbal medicine. Baicalein, wogonin, and oroxylin A are three major bioactive flavones in Radix Scutellariae and share similar chemical structures. The intestinal absorption and disposition of baicalein have been systematically investigated by our group
Runzhi Zhu et al.
PloS one, 8(8), e71612-e71612 (2013-08-21)
Based on the previous research that oroxylin A can suppress inflammation, we investigated the hepatoprotective role of oroxylin A against CCl₄-induced liver damage in mice and then studied the possible alteration of the activities of cytokine signaling participating in liver
Hong Wang et al.
PloS one, 8(7), e69555-e69555 (2013-08-08)
Oroxylin A, a natural flavonoid, is one of the main bioactive compounds that underlie the anti-inflammatory effect of the medicinal herb Scutellaria baicalensis Georgi widely used in southeastern Asia; however, the molecular mechanisms for the therapeutic benefits remain largely unclear.
Hui-Ying Yang et al.
Molecular carcinogenesis, 51(2), 185-195 (2011-05-11)
In this study, oroxylin A showed strong reversal potency in BEL7402/5-FU cells and the reversal fold (RF) reached 4.69. Simultaneously, rhodamine-123 accumulation assay and flow cytometry analysis demonstrated oroxylin A could increase drug accumulation. When combined with oroxylin A, 5-FU
Hien-trung Trinh et al.
Acta pharmacologica Sinica, 31(6), 718-724 (2010-05-11)
To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB). Baicalin was anaerobically incubated with human fecal microflora, and its metabolites, baicalein and oroxylin A, were isolated.
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