O0891
Oxymatrine
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About This Item
Empirical Formula (Hill Notation):
C15H24N2O2
CAS Number:
Molecular Weight:
264.36
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
Assay
≥98% (HPLC)
Quality Level
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23
InChI
1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChI key
XVPBINOPNYFXID-LHDUFFHYSA-N
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Biochem/physiol Actions
Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective. Traditional chinese medicine used in the treatment against hepatitis B virus.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
监管及禁止进口产品
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Li Gao et al.
Scientific reports, 8(1), 624-624 (2018-01-14)
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC)
Ning-Li Chai et al.
World journal of gastroenterology, 18(31), 4199-4206 (2012-08-25)
To investigate the potential mechanism of Arg-Gly-Asp (RGD) peptide-labeled liposome loading oxymatrine (OM) therapy in CCl₄-induced hepatic fibrosis in rats. We constructed a rat model of CCl₄-induced hepatic fibrosis and treated the rats with different formulations of OM. To evaluate
Ying Zhang et al.
Biochemical pharmacology, 85(1), 59-68 (2012-10-30)
The human ether-a-go-go-related gene (hERG) encodes the rapidly activating, delayed rectifier potassium channel (IKr) important for cardiac repolarization. Dysfunction of the hERG channel can cause Long QT Syndrome (LQTS). A wide variety of structurally diverse therapeutic compounds reduce the hERG
Ruoxi Fan et al.
Fitoterapia, 89, 271-277 (2013-06-12)
A rapid, sensitive and selective high-performance liquid chromatography mass spectrometric method has been developed and validated for the simultaneous determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution. Analytes were extracted from
Zhiqiang Wang et al.
International journal of oncology, 49(6), 2331-2340 (2016-10-18)
Lung cancer is the leading cause of cancer-related deaths worldwide and is associated with a very poor outcome. Oxymatrine exerts antitumor effects by inducing apoptosis and inhibiting the proliferation of different cancer cells; however, the anticancer effects and mechanism of
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