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O2375

Sigma-Aldrich

L-Ornithine monohydrochloride

≥99%

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Synonym(s):
(S)-2,5-Diaminopentanoic acid monohydrochloride
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
3184-13-2
Molecular Weight:
168.62
Beilstein:
3625847
EC Number:
221-678-6
MDL number:
MFCD00064562
PubChem Substance ID:
24897960
NACRES:
NA.26

Quality Level

200

Assay

≥99%

form

powder

impurities

ammonia and citrulline, essentially free

color

white

application(s)

cell analysis

SMILES string

Cl.NCCC[C@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

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Application

L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.

Biochem/physiol Actions

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.

Other Notes

Product of arginine degradation by arginase

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Arginase Activity in Human Breast Cancer Cell Lines: N?-Hydroxy-l-arginine Selectively Inhibits Cell Proliferation and Induces Apoptosis in MDA-MB-468 Cells
Rajan Singh
Cancer Research, 60(12) (2000)
Identification of bacteria potentially producing biogenic amines isolated from Venezuelan white cheese
Alba Lorena BENAVIDES Sierra
Revista Brasileira de Farmacognosia (2016)
THE EFFECT OF L-ORNITHINE ON THE INNER EAR OF RATS IN THE LIPOPOLYSACCHARIDE INDUCED ENDOTOXEMIA MODEL
Keal Gorur
Kulak Burun bo?az Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat (2018)
L-Ornithine affects peripheral clock gene expression in mice
Takafumi Fukuda
Scientific Reports (2016)
Nicole Berthold et al.
Antimicrobial agents and chemotherapy, 57(1), 402-409 (2012-11-02)
Proline-rich antimicrobial peptides (PrAMPs) from insects and mammals have recently been evaluated for their pharmaceutical potential in treating systemic bacterial infections. Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models.
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