O5502
S-Octylglutathione
suitable for ligand binding assays
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About This Item
Empirical Formula (Hill Notation):
C18H33N3O6S
CAS Number:
Molecular Weight:
419.54
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Product Name
S-Octylglutathione,
InChI
1S/C18H33N3O6S/c1-2-3-4-5-6-7-10-28-12-14(17(25)20-11-16(23)24)21-15(22)9-8-13(19)18(26)27/h13-14H,2-12,19H2,1H3,(H,20,25)(H,21,22)(H,23,24)(H,26,27)
SMILES string
CCCCCCCCSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O
InChI key
MJWCZWAVSJZQNL-UHFFFAOYSA-N
form
solid
technique(s)
ligand binding assay: suitable
storage temp.
2-8°C
Biochem/physiol Actions
S-octylglutathione is a competitive inhibitor for glutathione S-transferases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M Kurata et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 863-867 (1992-12-01)
1. Phenol compounds (ellagic acid, quercetin and purpurogallin), glutathione analogues (S-hexylglutathione and S-octylglutathione) and a diuretic drug (ethacrynic acid) were compared for their inhibitory effects on glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) in the canine erythrocytes.
M A Tirmenstein et al.
Biochimica et biophysica acta, 995(2), 174-180 (1989-04-06)
Glutathione protects isolated rat liver nuclei against lipid peroxidation by inducing a lag period prior to the onset of peroxidation. This GSH-dependent protection was abolished by exposing isolated nuclei to the glutathione S-transferase inhibitor S-octylglutathione. In incubations containing 0.2 mM
E Ortiz-Salmerón et al.
Biochimica et biophysica acta, 1548(1), 106-113 (2001-07-14)
The binding of three competitive glutathione analogue inhibitors (S-alkylglutathione derivatives) to glutathione S-transferase from Schistosoma japonicum, SjGST, has been investigated by isothermal titration microcalorimetry at pH 6.5 over a temperature range of 15--30 degrees C. Calorimetric measurements in various buffer
I Eberhardt et al.
Prostaglandins, 41(2), 185-199 (1991-02-01)
Pituitary cells produce leukotrienes (LTs) and respond to exogenous administration of LTs by releasing gonadotropins. Specific high affinity leukotriene C4 (LTC4) binding has been found in membrane preparations of bovine anterior pituitaries. Unlabelled LTC4 displaced specific [3H]LTC4 binding. Other leukotrienes
G Davidson et al.
Biochemistry, 40(15), 4569-4582 (2001-04-11)
Escherichia coli glyoxalase I (GlxI) is a metalloisomerase that is maximally activated by Ni(2+), unlike other known GlxI enzymes which are active with Zn(2+). The metal is coordinated by two aqua ligands, two histidines (5 and 74), and two glutamates
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