O6380
[Thr4, Gly7]-Oxytocin
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C39H61N11O12S2
CAS Number:
Molecular Weight:
940.10
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(N)=O
Amino Acid Sequence
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Biochem/physiol Actions
Neuropeptide synthesized in the hypothalamus and involved in the control of lactation and parturition; selective ligand for central and peripheral oxytocin receptors.
Signal Word
Warning
Hazard Statements
Hazard Classifications
Acute Tox. 4 Inhalation
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Christophe Breton et al.
The Journal of clinical endocrinology and metabolism, 87(3), 1415-1418 (2002-03-13)
In the present report, we provide for the first time evidence that functional oxytocin receptors (OTRs) are present in human myoblasts obtained from clonal cultures of postnatal satellite cells. First, binding studies performed with a non selective vasopressin (AVP) and
P Poulin et al.
Journal of neuroendocrinology, 5(1), 33-39 (1993-02-01)
The recent observation that the central oxytocin (OT) receptor has high affinity for both OT and arginine vasopressin (AVP) raises the possibility that it may be involved in some of the central actions of AVP. Repeated intracerebroventricular (icv) injections of
G C Harris et al.
The Journal of endocrinology, 156(1), 35-42 (1998-03-13)
Oxytocin (OT) is present in the mammalian testis and has been postulated to play a role in modulation of seminiferous tubule contractility. However, recent evidence suggests that the myoid cells responsible for such contractile activity do not express OT receptors.
M A Petty et al.
European journal of pharmacology, 112(2), 203-210 (1985-06-07)
In conscious, chronically instrumented normotensive male Wistar rats intravenous (i.v.) administration of oxytocin (OXT) (greater than or equal to 100 ng) induced a dose-related biphasic change in mean arterial pressure (MAP). This consisted of an initial pressor effect accompanied by
Anissa Benoussaidh et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 287(2), R446-R453 (2004-03-27)
The rat uterus receives an innervation from the lumbosacral and thoracolumbar segments of the spinal cord. These segments receive descending oxytocinergic projections from the paraventricular nucleus of the hypothalamus. We tested the hypothesis that oxytocin regulates uterine motility through a
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