O6380
[Thr4, Gly7]-Oxytocin
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C39H61N11O12S2
CAS Number:
Molecular Weight:
940.10
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(N)=O
Biochem/physiol Actions
Neuropeptide synthesized in the hypothalamus and involved in the control of lactation and parturition; selective ligand for central and peripheral oxytocin receptors.
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M Oz et al.
Journal of neurophysiology, 86(3), 1202-1210 (2001-09-06)
Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord. We sought to characterize their influence on neural excitability by using patch-clamp techniques to record AVP-induced responses from a population of motoneurons
M A Petty et al.
European journal of pharmacology, 112(2), 203-210 (1985-06-07)
In conscious, chronically instrumented normotensive male Wistar rats intravenous (i.v.) administration of oxytocin (OXT) (greater than or equal to 100 ng) induced a dose-related biphasic change in mean arterial pressure (MAP). This consisted of an initial pressor effect accompanied by
Central effects of oxytocin.
P Richard et al.
Physiological reviews, 71(2), 331-370 (1991-04-01)
P Jourdain et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(17), 6641-6649 (1998-08-26)
During lactation and parturition, magnocellular oxytocin (OT) neurons display a characteristic bursting electrical activity responsible for pulsatile OT release. We investigated this activity using hypothalamic organotypic slice cultures enriched in magnocellular OT neurons. As shown here, the neurons are functional
J Frayne et al.
Biology of reproduction, 52(6), 1268-1273 (1995-06-01)
The effect of the neurohypophysial hormones oxytocin and arginine vasopressin (AVP) on testicular steroidogenesis was reevaluated by use of short-term (< 10 h) cultures of isolated adult rat Leydig cells. Oxytocin at 10(-9), 10(-7), and 10(-5) M concentrations significantly increased
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