O6380
[Thr4, Gly7]-Oxytocin
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C39H61N11O12S2
CAS Number:
Molecular Weight:
940.10
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(N)=O
Amino Acid Sequence
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Biochem/physiol Actions
Neuropeptide synthesized in the hypothalamus and involved in the control of lactation and parturition; selective ligand for central and peripheral oxytocin receptors.
Signal Word
Warning
Hazard Statements
Hazard Classifications
Acute Tox. 4 Inhalation
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Neurotransmitter and neurohormonal regulation of oxytocin secretion in lactation.
W R Crowley et al.
Annals of the New York Academy of Sciences, 652, 286-302 (1992-06-12)
The role of oxytocin: present concepts.
J S Jenkins et al.
Clinical endocrinology, 34(6), 515-525 (1991-06-01)
B Chini et al.
FEBS letters, 397(2-3), 201-206 (1996-11-18)
We investigated the mechanisms that regulate the efficacy of agonists in the arginine-vasopressin (AVP)/oxytocin (OT) receptor system. In this paper, we present evidence that AVP, a full agonist of the vasopressin receptors, acts as a partial agonist on the oxytocin
E Politowska et al.
Journal of receptor and signal transduction research, 22(1-4), 393-409 (2002-12-31)
The aim of the study was to computer-dock selected ligands to neurophyseal receptors in order to identify amino acid residues responsible for ligand-receptor interactions. To this aim, reliable oxytocin receptor (OTR) and arginine-vasopressin receptor (V1aR/V2R) models were built. The OTR-selective
J Elands et al.
The American journal of physiology, 254(1 Pt 1), E31-E38 (1988-01-01)
Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors. For this purpose, a highly specific oxytocic agonist [Thr4,Gly7]oxytocin was tritiated. We demonstrated that this ligand labels oxytocin receptors selectively. Scatchard analyses revealed
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