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Merck
CN

O7389

Sigma-Aldrich

Olprinone hydrochloride

≥98% (HPLC), solid

Synonym(s):

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H10N4O · HCl
CAS Number:
119615-63-3
Molecular Weight:
286.72
MDL number:
MFCD01749474
UNSPSC Code:
41106305
PubChem Substance ID:
24724566
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL
H2O: 6.8 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
056K47151
056K4715

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Kiyoto Nishi et al.
Journal of cardiology, 59(3), 366-373 (2012-03-01)
The ambulatory treatment of advanced heart failure (HF) with intermittent infusions of inotropes or natriuretic peptide chosen immediately before each infusion has not been described. Between May 2005 and July 2009, we treated 11 patients presenting with advanced HF, who
Mayumi Tachikawa et al.
Masui. The Japanese journal of anesthesiology, 61(6), 566-573 (2012-07-04)
Beta blockers are frequently used to reduce cardiac oxygen demand in off-pump coronary artery bypass grafting (OPCAB). However, significant bradycardia or negative inotropic effects are seen on occasion. We hypothesized that combined use of landiolol (L), an ultra short-acting beta
Katsushi Kinouchi et al.
General thoracic and cardiovascular surgery, 60(2), 73-81 (2012-02-14)
The benefit of terminal blood cardioplegia (TWBCP) is insufficient after prolonged ischemia associated with inevitable oxidant-mediated injury by this modality alone. We tested the effects of TWBCP supplemented with high-dose olprinone, which is a phosphodiesterase III inhibitor, a clinically available
Hirofumi Oishi et al.
American journal of physiology. Lung cellular and molecular physiology, 303(2), L130-L140 (2012-05-23)
Olprinone, a specific phosphodiesterase III inhibitor, and corforsin daropate, a direct adenylate cyclase activator, are now being used in critical conditions. We investigated whether their therapeutic use provides protection against septic acute lung injury (ALI) and mortality. Polymicrobial sepsis was
Shinya Yamazaki et al.
Anesthesia progress, 58(1), 22-25 (2011-03-18)
Left ventricular noncompaction (LVNC), also known as spongiform cardiomyopathy, is a severe disease that has not previously been discussed with respect to general anesthesia. We treated a child with LVNC who experienced cardiac arrest. Dental treatment under general anesthesia was
View All Related Papers

Articles

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

磷酸二酯酶类

环核苷酸磷酸二酯酶 (PDEs) 催化 cAMP 和/或 cGMP 的水解。存在有11种不同的哺乳动物PDE家族。

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