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O9012

Oxonol V

Name: Oxonol V
Brand: SIGMA

Synonym(s):

1,5-Penta-1,3-dien-1-yl-5-ylidene-bis(5-oxo-3-phenyl-4-isoxazole), 4-[5-(5-Hydroxy-3-phenyl-4-isoxazolyl)-2,4-pentadienylidene]-3-phenyl-5(4H)-isoxazolone

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₁₆N₂O₄

CAS Number:

61389-30-8

Molecular Weight:

384.38

PubChem Substance ID:

329818932

Beilstein/REAXYS Number:

575970

MDL number:

MFCD00075232

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Properties

SMILES string

Oc1onc(-c2ccccc2)c1\C=C\C=C\C=C3/C(=O)ON=C3c4ccccc4

InChI

1S/C23H16N2O4/c26-22-18(20(24-28-22)16-10-4-1-5-11-16)14-8-3-9-15-19-21(25-29-23(19)27)17-12-6-2-7-13-17/h1-15,26H/b9-3+,14-8+,19-15-

InChI key

NEDZCQDBZLHEGJ-UFRBDIPQSA-N

Description

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Use of oxonol V as a probe of membrane potential in proteoliposomes containing cytochrome oxidase in the submitochondrial orientation.

C E Cooper et al.

Biochemistry, 29(16), 3859-3865 (1990-04-24)

Absorbance changes in the anionic dye bis[3-phenyl-5-oxoisoxazol-4-yl]pentamethineoxonol (oxonol V) can be used to monitor the membrane potential of liposomes and cytochrome c containing cytochrome oxidase proteoliposomes (c-loaded COV). Diffusion potentials (positive inside the vesicles) cause an increase in the dye

Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles.

Chengyong Liao et al.

European journal of pharmacology, 566(1-3), 103-112 (2007-04-24)

This research examines the effects of ethanolamine and other amino alcohols on the dynamics of acridine orange (AO), oxonol V, and [3H]-D-aspartic acid in synaptic preparations isolated from mammalian brain. Ethanolamine concentration-dependently enhanced AO release from synaptosomes. Similar effects were

Electrogenic H+ translocation by the plasma membrane ATPase of Neurospora. Studies on plasma membrane vesicles and reconstituted enzyme.

D S Perlin et al.

The Journal of biological chemistry, 259(12), 7884-7892 (1984-06-25)

Fluorescent probes have been used to measure electrogenic proton pumping by the plasma membrane ATPase of Neurospora. In isolated plasma membrane vesicles, greater than 85% of which are inverted, ATP hydrolysis is accompanied by the formation of an inside acid

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