P0035
Penciclovir
Synonym(s):
2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123
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About This Item
Empirical Formula (Hill Notation):
C10H15N5O3
CAS Number:
Molecular Weight:
253.26
NACRES:
NA.76
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
form
powder
Quality Segment
solubility
0.02 M potassium phosphate: soluble 2 mg/mL
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChI key
JNTOCHDNEULJHD-UHFFFAOYSA-N
Application
Biochem/physiol Actions
Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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