P0059
Pro-carboxypeptidase B human
≥2.0 units/mg protein
Synonym(s):
Thrombin Activatable Fibrinolysis Inhibitor (TAFI)
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About This Item
Specific activity:
≥2.0 units/mg protein
Quality Segment
specific activity
≥2.0 units/mg protein
mol wt
60 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CPB1(1360)
Biochem/physiol Actions
TAFI is supplied in its 60 kDa zymogen form. The N-terminal of TAFI contains four N-linked glycans and a plasminogen recognition sequence. Hydrolysis of the activation peptide by thrombin releases a 36-kDa active proteolytic domain homologous to tissue carboxypeptidase B. Complexation with thrombomodulin increases thrombin activation of TAFI 1250 fold. TAFI exerts it′s inhibition of fibrinolytic activity by binding to plasminogen and by cleaving C-terminal lysine residues of fibrin resulting in the reduction of plasmin and tPA binding sites on fibrin. Experiments in TAFI-deficient mice point to a regulatory role on complement C5a.
Physical form
Solution containing 20 mM Hepes and 150 mM Sodium chloride. pH 7.4
Other Notes
One unit will hydrolyze 1 micromole of Hippuryl-L-Arginine per minute at pH 7.4 at 25 °C.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| P0059-50UG | 04061838032218 |