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P0106

Sigma-Aldrich

Pefloxacin mesylate dihydrate

Synonym(s):

3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate, Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate

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100 μL
CN¥4,383.64

CN¥4,383.64

Estimated to ship onJuly 22, 2025Details

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100 μL
CN¥4,383.64

About This Item

Linear Formula:
C17H20FN3O3 • CH4O3S • 2H2O
CAS Number:
149676-40-4
Molecular Weight:
465.49
EC Number:
274-613-9
MDL number:
MFCD01685696
UNSPSC Code:
51102829
PubChem Substance ID:
329820015
NACRES:
NA.76

CN¥4,383.64

Estimated to ship onJuly 22, 2025Details

Request a Bulk Order

form

powder

Quality Level

100

solubility

H2O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

SMILES string

O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3

InChI

1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2

InChI key

LEULAXMUNMRLPW-UHFFFAOYSA-N

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酚红 powder, BioReagent, suitable for cell culture

P3532

酚红

酚红 ACS reagent

114529

酚红

酚红 溶液 liquid, 0.5%, sterile-filtered, BioReagent, suitable for cell culture

P0290

酚红 溶液

酚红 indicator ACS

107241

酚红

technique(s)

cell culture | mammalian: suitable

technique(s)

titration: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

color

dark red to dark brown

color

-

color

-

color

-

form

powder

form

powder

form

liquid

form

solid

solubility

1 M NaOH: 1 mg/mL

solubility

water: 0.77 g/L at 100 °C

solubility

-

solubility

-

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

application(s)

-

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

2-30°C

General description

Chemical structure: fluoroquinolone

Application

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents[1]. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes[2].

Biochem/physiol Actions

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.
Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin.
Mode of Action: Pefloxacin prevents bacterial DNA replication by inhibiting DNA gyrase.
Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa. Active against gram-positive bacteria and excellent activity against gram-negative bacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    MKBZ1643V
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    SLBG8950V
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    110M1325V

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    Biophysical aspects of in vivo tissue microenvironments include microscale mechanical properties, fibrillar alignment, and architecture or topography of the extracellular matrix (ECM). These aspects act in concert with chemical signals from a myriad of diverse ECM proteins to provide cues

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