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Merck
CN

P0109

Sigma-Aldrich

Phytic acid sodium salt hydrate

from rice, ≥90% phosphorus (P) basis

Synonym(s):

myo-Inositol hexakis(dihydrogen phosphate), Inositol hexakisphosphate, Inositol hexaphosphoric acid, InsP6

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About This Item

Empirical Formula (Hill Notation):
C6H18O24P6 · xNa+ · yH2O
CAS Number:
Molecular Weight:
660.04 (anhydrous free acid basis)
EC Number:
UNSPSC Code:
12352201
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biological source

rice

Assay

≥90% phosphorus (P) basis

composition

Sodium, ≥10 mol/mol ICP

impurities

≤0.1% Inorganic phosphorus

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)O[C@H]1[C@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O

InChI

1S/C6H18O24P6.12Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;/q;12*+1/p-12

InChI key

KETSPIPODMGOEJ-UHFFFAOYSA-B

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General description

Phytic acid is a major determinant of zinc bioavailability.

Application

Recommended for use as phytase substrate due to low inorganic phosphorus content. Phytic acid has been used as an anti-nutrient factor in a study to assess the effect of processing on the African locust bean. It has also been used in a study to investigate the effect of dietary rice bran component γ-oryzanol on tumor growth.

Biochem/physiol Actions

Phytic acid is present in all eukaryotic cells. In plants, it is known to function as a [PO4]3− storage depot and precursor for other inositol phosphates and pyrophosphates. Its high surface negative charge makes it a potent chelator of divalent and trivalent cations in vitro, and it is most likely associated with Ca2+ or Mg2+ ions in vivo. In yeast, phytic acid acts with the nuclear pore protein Gle1 to regulate the nuclear export of mRNA by coactivating the RNA-dependent ATPase activity of DExD-box protein 5 (Dbp5).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Antonio Ariza et al.
PloS one, 8(5), e65062-e65062 (2013-06-07)
Phytases hydrolyse phytate (myo-inositol hexakisphosphate), the principal form of phosphate stored in plant seeds to produce phosphate and lower phosphorylated myo-inositols. They are used extensively in the feed industry, and have been characterised biochemically and structurally with a number of
Nusrat Ali et al.
PloS one, 8(7), e68161-e68161 (2013-07-12)
Phytic acid (InsP(6)) is considered to be the major source of phosphorus and inositol phosphates in most cereal grains. However, InsP(6) is not utilized efficiently by monogastric animals due to lack of phytase enzyme. Furthermore, due to its ability to
Ikootobong Sunday Urua et al.
International journal of food sciences and nutrition, 64(1), 94-102 (2012-07-14)
Proximate composition, amino acid levels and anti-nutrient factors (polyphenols, phytic acid and oxalate) in the seeds of Parkia biglobosa were determined at three stages: raw, boiled and fermented. The highest anti-nutrient factor present in the raw state was oxalate, while
Sung Phil Kim et al.
Molecular nutrition & food research, 56(6), 935-944 (2012-06-19)
We investigated the effects of rice bran and components on tumor growth in mice. Mice fed standard diets supplemented with rice bran, γ-oryzanol, Ricetrienol®, ferulic acid, or phytic acid for 2 weeks were inoculated with CT-26 colon cancer cells and
L de P Naves et al.
Asian-Australasian journal of animal sciences, 27(7), 1003-1012 (2014-07-23)
The use of a suitable methodology to quantify the phytate phosphorus (Pphy) content in both the feed and the excreta from broilers is required to enable accurate calculation of the catalytic efficiency of the phytase supplemented in the feed. This

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