P0248
PNU-37883A
≥98% (HPLC), powder
Synonym(s):
N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H36ClN3O
CAS Number:
Molecular Weight:
381.98
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: ~23 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5
Gene Information
human ... KCNJ8(3764)
Biochem/physiol Actions
Selective inhibitor of Kir6.1/SUR2B channels.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Bobby D Nossaman et al.
Journal of cardiovascular pharmacology, 50(4), 358-366 (2007-12-01)
The free radical peroxynitrite (ONOO-) is formed in biological systems from the reaction of nitric oxide (NO) with superoxide (O2-) and can react with protein and nonprotein thiol groups to produce tissue injury. However, these pathologic actions of (ONOO-) may
H Kovalev et al.
British journal of pharmacology, 141(5), 867-873 (2004-02-06)
1. In this study, we have used Kir6.1/Kir6.2 chimeric proteins and current recordings to investigate the molecular basis of PNU-37883A inhibition of cloned K(ATP) channels. 2. Rat Kir6.1, Kir6.2 and Kir6.1/Kir6.2 chimeras were co-expressed with either SUR2B or SUR1, following
Toshihisa Tomoda et al.
European journal of pharmacology, 524(1-3), 1-10 (2005-10-26)
The effects of U-37883A, a vascular ATP-sensitive K(+) channel (K(ATP) channel) blocker, on membrane currents were investigated in pig urethral myocytes by use of patch-clamp techniques (conventional whole-cell recordings, nystatin-perforated patches and cell-attached configuration). Tension measurement was also performed to
Yi-Ling Chan et al.
Critical care medicine, 40(4), 1261-1268 (2012-03-20)
Excessive opening of the adenosine triphosphate-sensitive potassium channel in vascular smooth muscle is implicated in the vasodilation and vascular hyporeactivity underlying septic shock. Therapeutic channel inhibition using sulfonylurea agents has proved disappointing, although agents acting on its pore appear more
Noriyoshi Teramoto
Cardiovascular drug reviews, 24(1), 25-32 (2006-08-31)
U-37883A (PNU-37883A, guanidine; 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl hydrochloride) was originally developed as a potential diuretic with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells. U-37883A inhibits ATP-sensitive K(+) channels (K(ATP) channels) in vascular smooth muscle
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