P0248
PNU-37883A
≥98% (HPLC), powder
Synonym(s):
N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H36ClN3O
CAS Number:
Molecular Weight:
381.98
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
color
white
SMILES string
Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ~23 mg/mL, H2O: insoluble
storage temp.
2-8°C
Gene Information
human ... KCNJ8(3764)
Biochem/physiol Actions
Selective inhibitor of Kir6.1/SUR2B channels.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Joy H Tan et al.
The Journal of physiology, 581(Pt 2), 757-765 (2007-03-24)
In rat tail artery, activation of postjunctional alpha(2)-adrenoceptors by noradrenaline (NA) released from sympathetic axons produces a slow depolarization (NAD) of the smooth muscle through a decrease in K(+) conductance. In this study we used intracellular recording to investigate whether
H C Champion et al.
Peptides, 22(9), 1427-1434 (2001-08-22)
Responses to human calcitonin gene-related peptide (hCGRP) and human adrenomedullin (hADM) hAmylin were investigated in isolated mesenteric resistance arteries from the rat. The results of the present investigation show that hCGRP, hAmylin, and hADM induce dose-related vasodilator responses in isolated
Yi-Ling Chan et al.
Critical care medicine, 40(4), 1261-1268 (2012-03-20)
Excessive opening of the adenosine triphosphate-sensitive potassium channel in vascular smooth muscle is implicated in the vasodilation and vascular hyporeactivity underlying septic shock. Therapeutic channel inhibition using sulfonylurea agents has proved disappointing, although agents acting on its pore appear more
Noriyoshi Teramoto
Cardiovascular drug reviews, 24(1), 25-32 (2006-08-31)
U-37883A (PNU-37883A, guanidine; 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl hydrochloride) was originally developed as a potential diuretic with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells. U-37883A inhibits ATP-sensitive K(+) channels (K(ATP) channels) in vascular smooth muscle
Toshihisa Tomoda et al.
European journal of pharmacology, 524(1-3), 1-10 (2005-10-26)
The effects of U-37883A, a vascular ATP-sensitive K(+) channel (K(ATP) channel) blocker, on membrane currents were investigated in pig urethral myocytes by use of patch-clamp techniques (conventional whole-cell recordings, nystatin-perforated patches and cell-attached configuration). Tension measurement was also performed to
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