P0307
Poly(deoxyadenylic-deoxycytidylic) acid • Poly(deoxyguanylic-thymidylic) acid sodium salt
Synonym(s):
Poly(2′-deoxyadenyl-2′-deoxycytidylicacid) · Poly(2′-deoxyguanylthymidylic acid) sodium salt, Poly(dA-dC) • Poly(dG-dT) sodium salt
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About This Item
storage temp.
−20°C
Application
Poly(deoxyadenylic-deoxycytidylic) acid • Poly(deoxyguanylic-thymidylic) acid (Poly(dA-dC) • Poly(dG-dT)) is a double-stranded alternating copolymer DNA model for conformational studies of DNA structure dynamics and drug interaction.
Other Notes
Double-stranded alternating copolymer; model for conformational studies of DNA.
One unit will yield an A260 of 1.0 in 1.0 ml of 0.1 M NaCl and 0.01 M potassium phosphate, pH 7.0 (1 cm light path).
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Chris T Middleton et al.
Annual review of physical chemistry, 60, 217-239 (2008-11-18)
Ultraviolet light is strongly absorbed by DNA, producing excited electronic states that sometimes initiate damaging photochemical reactions. Fully mapping the reactive and nonreactive decay pathways available to excited electronic states in DNA is a decades-old quest. Progress toward this goal
Anil Kumar et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 10(9-10), 1426-1430 (2009-03-25)
Low-energy electrons (LEEs) interact with a DNA model system to create a variety of excited states. In the gas phase, dissociative (sigma*) states are accessible by LEEs with energy <4 eV (see picture) and cause facile strand breaks through a
Ville Laitala et al.
Analytical chemistry, 77(5), 1483-1487 (2005-03-01)
We report here a novel, time-resolved, lanthanide-based energy-transfer assay utilizing nonoverlapping acceptor fluorophores, which have their absorption energetically at a higher level than the emittive transitions of the donor. The technique was studied by comparing a series of nonoverlapping acceptors