P0391
5α-Pregnane-3β,11β,21-triol-20-one
Synonym(s):
3β,11β,21-Trihydroxy-5α-pregnan-20-one, 3β,5α-Tetrahydrocorticosterone, 3β-Allotetrahydrocorticosterone, Allopregnane-3β,11β,21-triol-20-one, Reichstein’s substance R
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About This Item
Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
Molecular Weight:
350.49
UNSPSC Code:
41116107
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Y B Saalmann et al.
Journal of neuroendocrinology, 19(4), 272-284 (2007-03-16)
The 3alpha-hydroxy,5alpha-reduced pregnane steroids, allopregnanolone and allotetrahydrodeoxycorticosterone, are the most potent endogenous positive modulators of GABA(A) receptor-mediated inhibition. This study presents the first immunohistochemical examination of the cellular distribution of 3alpha-hydroxy,5alpha-reduced pregnane steroids across the brain. We found a widespread
A Soro et al.
Journal of human hypertension, 9(6), 391-393 (1995-06-01)
In a large group of patients with untreated hypertension, excretion rates of tetrahydrocorticosterone (THB), allotetrahydrocorticosterone (alloTHB) and tetrahydro-11-dehydrocorticosterone (THA) were all significantly higher than in a group of matched normotensive controls. Using the sum of these metabolites as an index
Kendall D W Morris et al.
Molecular pharmacology, 66(1), 56-69 (2004-06-24)
Rho(1) receptor-channels (rho(1)Rs) are GABA-gated chloride channels that exhibit slow kinetics, little desensitization, and inert pharmacology to most anesthetics, except for neuroactive steroids (NSs). NSs differentially modulate rho(1)Rs dependent on the steric arrangement of the hydrogen atom at the fifth
L Trachsel et al.
The European journal of neuroscience, 8(2), 319-328 (1996-02-01)
Infrared light transmittance imaging was used in rat hypothalamic slices to record an intrinsic optical signal (IOS) of the cell ensemble in the suprachiasmatic nuclei (SCN), the locus of the endogenous circadian clock. Upon optic chiasm stimulation, a transient IOS
R A Tigranian et al.
Endocrinologia experimentalis, 14(1), 3-7 (1980-03-01)
The urinary excretion of 17-hydroxycorticosteroids and the relations between the glucocorticoids in urine and their precursors as well as between 17-hydroxycorticoids and 17-hydroxycorticoids and 17-dehydroxycorticosteroids was measured in two subjects before and after 8 days flight in spaceship "Soyuz-22". During
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