P1132
Pterine
~95%
Synonym(s):
2-Amino-4-hydroxypteridine, 2-Amino-4-oxodihydropteridine
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About This Item
Empirical Formula (Hill Notation):
C6H5N5O
CAS Number:
Molecular Weight:
163.14
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
218-799-1
Beilstein/REAXYS Number:
150294
MDL number:
biological source
synthetic
Quality Level
assay
~95%
form
powder
storage temp.
2-8°C
SMILES string
Nc1nc(O)c2nccnc2n1
InChI
1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12)
InChI key
HNXQXTQTPAJEJL-UHFFFAOYSA-N
Application
Pterine has been used:
- in photochemicals assay for inducing DNA damage
- as a substrate in xanthine oxidase assay
- as a standard in thin layer chromatography (TLC) for quantifying pterine from microbes
Biochem/physiol Actions
Pterine consists of pyrazine and pyrimidine with substitutions in keto and amino group. Pterine is present in all organisms including cyanobacteria. It acts as a cofactor for redox enzymes and serves as a precursor for folic acid synthesis. Pterine from the butterfly wings absorb light and elicit incoherent scattering. Pterine induces alterations in DNA by hydroxylation of deoxyguanosine.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK
Nomura J, et al.
PLoS ONE, 8(9), e75527-e75527 (2013)
Andrea Sariego-Jamardo et al.
Pediatric neurology, 53(5), 422-426 (2015-10-18)
The mechanisms of the ketogenic diet remain unclear, but several predictors of response have been proposed. We aimed is to study the relationship between the etiology of epilepsy, cerebrospinal fluid neurotransmitters, pterins, and amino acids, and response to a ketogenic
Evaluation of Pterin, a Promising Drug Candidate from Cyanide Degrading Bacteria
Mahendran R, et al.
Current Microbiology, 75(6), 684-693 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P1132-1G | 04061826016909 |
| P1132-250MG | 04061834354017 |
| P1132-50MG | 04061834354024 |