P1134
Porphobilinogen
powder
Synonym(s):
5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
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About This Item
Empirical Formula (Hill Notation):
C10H14N2O4
CAS Number:
Molecular Weight:
226.23
UNSPSC Code:
12352204
NACRES:
NA.83
PubChem Substance ID:
EC Number:
207-666-3
Beilstein/REAXYS Number:
220051
MDL number:
InChI key
QSHWIQZFGQKFMA-UHFFFAOYSA-N
InChI
1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)
SMILES string
NCc1[nH]cc(CCC(O)=O)c1CC(O)=O
assay
≥96% (HPLC)
form
powder
solubility
1 M NH4OH: 10 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Intermediate in the biosynthesis of heme.
Preparation Note
Enzymatically prepared.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Xinfu Zhang et al.
The Journal of organic chemistry, 77(1), 669-673 (2011-11-25)
In the orignial 1,3,5,7-tetraphenyl aza-BODIPY, replacing the phenyl rings with thiophene achieved significant bathochromic shifts. One of the target molecules, DPDTAB, emitting strong NIR fluorescence with a quantum yield of 0.46 in acetonitrile, is a very competitive NIR fluorophore.
Joanne T Marsden et al.
Journal of clinical pathology, 67(1), 60-65 (2013-08-03)
The porphyrias are a group of rare, mainly inherited, diseases caused by a deficiency of one of the enzymes of the haem biosynthesis pathway. The biochemical hallmark of an acute attack is an increase in urine porphobilinogen (PBG), together with
Ton Schoenmaker et al.
Frontiers in endocrinology, 11, 501-501 (2020-08-08)
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by heterotopic ossification (HO) that occurs in muscle tissue, tendons, and ligaments. The disease is caused by mutations in the Activin receptor type I (ACVR1) gene resulting in enhanced responsiveness
Bingshuai Wang et al.
Chemical communications (Cambridge, England), 49(10), 1014-1016 (2012-12-22)
We have developed a new reversible fluorescence probe MPhSe-BOD for the redox cycle process between hypochlorous acid and hydrogen sulfide in solution and in living cells. Confocal microscopy imaging using RAW264.7 cell lines shows that the probe has good cell
Cilly Bernardette Schnider et al.
Frontiers in cellular and infection microbiology, 10, 464-464 (2020-10-06)
An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment
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