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P1378

Phthaldialdehyde

Name: Phthaldialdehyde
Brand: SIGMA

≥97% (HPLC), powder or crystals

Synonym(s):

o-Phthalaldehyde, o-Phthalic dicarboxaldehyde, Benzene-1,2-dicarboxaldehyde, OPA

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About This Item

Empirical Formula (Hill Notation):

C₈H₆O₂

CAS Number:

643-79-8

Molecular Weight:

134.13

UNSPSC Code:

12352201

NACRES:

NA.21

PubChem Substance ID:

24898191

EC Number:

211-402-2

Beilstein/REAXYS Number:

878317

MDL number:

MFCD00003335

Assay:

≥97% (HPLC)

Form:

powder or crystals

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Quality Level

200

assay

≥97% (HPLC)

form

powder or crystals

color

white to light yellow

mp

55-58 °C

storage temp.

2-8°C

SMILES string

O=Cc1ccccc1C=O

InChI

1S/C8H6O2/c9-5-7-3-1-2-4-8(7)6-10/h1-6H

InChI key

ZWLUXSQADUDCSB-UHFFFAOYSA-N

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Related Categories

Chemical Biology

Protein Degrader Building Blocks

Application

Phthaldialdehyde has been used:

to detect Arg through spectrophotometry using end-point fluorescent sensitive detection
as a reagent stream with the sample to produce a fluorescent product for determining ammonia in seawater
in the o-phthaldialdehyde spectrophotometric assay (OPA test) to determine the proteolytic activity (PA)of the strains and the commercial cultures

Biochem/physiol Actions

o-Phthaldialdehyde (OPA) can form fluorescent derivatives while reacting with amino acids.

Phthaldialdehyde can be used for the pre-column derivatization of amino acids for high-performance liquid chromatography (HPLC) separation. It may also be used for flow cytometric measurements of protein thiol groups.

pictograms

GHS06,GHS05,GHS09

signalword

Danger

hcodes

H301,H314,H317,H335,H410

pcodes

P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

269.6 °F - closed cup

flash_point_c

132 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction.

Bianca de Moraes Fracasso et al.

PloS one, 14(1), e0209964-e0209964 (2019-01-12)

Circulating advanced glycation end products (AGE) and their receptor, RAGE, are increased after a myocardial infarction (MI) episode and seem to be associated with worse prognosis in patients. Despite the increasing importance of these molecules in the course of cardiac

Derivatization and chromatographic behavior of the o-phthaldialdehyde amino acid derivatives obtained with various SH-group-containing additives.

I Molnár-Perl

Journal of chromatography. A, 913(1-2), 283-302 (2001-05-18)

An overview is presented of HPLC methods currently in use to determine amino acids as their o-phthaldialdyde derivatives in the presence of various SH-group-containing additives. Crucial points that proved to influence the stability of the amino acid OPA derivatives have

Selective extraction of thiol-containing peptides in seawater using Tween 20-capped gold nanoparticles followed by capillary electrophoresis with laser-induced fluorescence.

Chien-Chih Shen et al.

Journal of chromatography. A, 1220, 162-168 (2011-12-22)

This study combines Tween 20-capped gold nanoparticles (Tween 20-AuNPs) with capillary electrophoresis (CE) for ultrasensitive detection of thiol-containing peptides, including glutathione (GSH), γ-glutamylcysteine (γ-GCS), and phytochelatin analogs. By forming AuS bonds, Tween 20-AuNPs can selectively extract and enrich these thiols

Gold nanoparticle extraction followed by o-phthaldialdehyde derivatization for fluorescence sensing of different forms of homocysteine in plasma.

Yi-Jhen Lai et al.

Talanta, 91, 103-109 (2012-03-01)

This study reports a selective and sensitive method for fluorescent detection of total, protein-bound, free, and free oxidized homocysteine (HCys) using tris(2-carboxyethyl)phosphine (TCEP) as a reducing agent, fluorosurfactant-capped gold nanoparticles (FSN-AuNP) as a preconcentrating probe, and o-phthaldialdehyde (OPA) as a

Sphingosine in plants--more riddles from the Sphinx?

M Nurul Islam et al.

The New phytologist, 193(1), 51-57 (2011-11-11)

• Sphingolipids are emerging as important mediators of cellular and developmental processes in plants, and advances in lipidomics have yielded a wealth of information on the composition of plant sphingolipidomes. Studies using Arabidopsis thaliana showed that the dihydroxy long-chain base

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Global Trade Item Number

SKU	GTIN
P1378-1G	04061835547395
P1378-5G	04061835547418
P1378-100G	04061834354598
P1378-25G	04061835547401

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