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Merck
CN

P1489

Protein Kinase p34CDC2 Substrate

≥90% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C106H172N32O32
Molecular Weight:
2406.70
UNSPSC Code:
12352200
MDL number:
MFCD00171630

Key Documents

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SMILES string

CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(O)=O

assay

≥90% (HPLC)

solubility

H2O: soluble

UniProt accession no.

D4A058

storage temp.

−20°C

Gene Information

rat ... CDK1 (CDC2)

Biochem/physiol Actions

Highly specific substrate of p34cdc2 protein kinase, which is an enzyme involved in mitosis and S phase onset

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
072K0331
083K1188
071K1366

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D S O'Connor et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(24), 13103-13107 (2000-11-09)
The interface between apoptosis (programmed cell death) and the cell cycle is essential to preserve homeostasis and genomic integrity. Here, we show that survivin, an inhibitor of apoptosis over-expressed in cancer, physically associates with the cyclin-dependent kinase p34(cdc2) on the

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